661471-80-3

Upstream product

• 672298-89-4 3',5'-di-O-acetyl-2'-O-{[(triisopropylsilyl)oxy]methyl}inosine 
• 2140-73-0 1-methylinosine 
• 58-63-9 Inosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 217300-17-9 chloromethoxy-triisopropyl-silane 
• 236752-17-3 5'-O-(4,4'-dimethoxytrityl)-1-methylinosine 

Relevant academic research and scientific papers

Synthesis of 2′-O-[(triisopropylsilyl)oxy]methyl (=tom)-protected ribonucleoside phosphoramidites containing various nucleobase analogues

The first results of a study aiming at an efficient preparation of a large variety of 2′-O-[(triisopropylsilyl)oxy]methyl(=tom)-protected ribonucleoside phosphoramidite building blocks containing modified nucleobases are reported. All of the here presente

The Synthesis of 2′-O-[(Triisopropylsilyl)oxy] methyl (TOM) Phosphoramidites of Methylated Ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for Use in Automated RNA Solid-Phase Synthesis

The straightforward synthesis of eight methylated ribonucleoside phosphoramidites is described. These building blocks allow for incorporation of the naturally occuring nucleosides 1-methylguanosine (m1G), N 2-methylguanosine (m2G), N2N 2-dimethylguanosine (m22G), 1-methylinosine (m1I), 3-methyluridine (m3U), N4- methylcytidine (m4C), N6-methyladenosine (m6A), and N6,N6-dimethyladenosine (m62A) into oligoribonucleotides by automated RNA solid-phase synthesis. In all cases, the ribose 2′-hydroxyl group of the building blocks is masked by the recently introduced [(triisopropylsilyl)oxy]methyl (TOM) group.