66156-19-2Relevant academic research and scientific papers
Metal and Solvent-Free Synthesis of 2H-Pyrido[1,2-a]pyrimidin-2-ones Catalyzed by Elemental Sulfur
Pavithra, Thangavel,Devi, E. Sankari,Nagarajan, Subbiah,Sridharan, Vellaisamy,Maheswari, C. Uma
, p. 6884 - 6887 (2019)
The efficiency of elemental sulfur for the synthesis of 2H-pyrido[1,2-a]pyrimidin-2-ones has been demonstrated. This strategy involves coupling of 2-aminopyridines and β-oxo esters under neat condition in the absence of external oxidant. The reaction does not require pre-functionalization of the substrates, thus making it an alternate approach for the synthesis of 2H-pyrido[1,2-a]pyrimidin-2-ones. The reaction was tolerant to several substituted 2-aminopyridines and β-oxo esters.
Copper(II)/iron(III) co-catalyzed intermolecular diamination of alkynes: Facile synthesis of imidazopyridines
Zeng, Jing,Tan, Yu Jia,Leow, Min Li,Liu, Xue-Wei
supporting information, p. 4386 - 4389 (2012/10/29)
A facile synthesis of imidazo[1,2-α]pyridines has been achieved by copper(II) and iron(III) co-catalyzed C-N bond formation. This reaction involves an intermolecular oxidative diamination of alkynes with high chemoselectivity and regioselectivity.
Synthesis of 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-ones utilizing activated alkynoates
Harriman, Geraldine C. B.,Chi, Shannon,Zhang, Min,Crowe, Andrea,Bennett, Robert A.,Parsons, Ian
, p. 3659 - 3662 (2007/10/03)
The synthesis of the biologically relevant, 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-one 7, is reported. Addition of substituted 2-aminopyridines 5 to activated alkynoates leads to the facile formation of a series of metabolically stable trifluoromethyl substituted pyrido[1,2-a]pyrimidines under mild conditions.
