66166-28-7Relevant articles and documents
Improved synthesis of oxazoline under microwave irradiation
Oussaid,Berlan,Soufiaoui,Garrigues
, p. 659 - 665 (1995)
Oxazolines have been prepared under microwave irradiation in two different ways. In the first one, imino ether hydrochlorides have been reacted with amino alcohols in the presence of alumina supported potassium fluoride, in an open vessel. In the second o
A Reinvestigation of the Pictet-Gams Isoquinoline Synthesis. Part 2. Formation of Rearranged Isoquinolines: the Δ2-Oxazoline-Isoquinoline Transformation
Ardabilchi, Nasser,Fitton, Alan O.,Hadi, A. Hamid b. A.,Thompson, J. Robin
, p. 1710 - 1725 (2007/10/02)
Cyclisation of a series of 2-substituted 2-acylamino-1-arylalkan-1-ols using phosphorus pentaoxide in refluxing decalin is shown to lead to rearranged, i.e. 4-substituted, isoquinolines in addition to the anticipated 3-substituted isomers.The products arise largely via 5-phenyl-Δ2-oxazoline intermediates and the formation of the rearranged isoquionolines from these intermediates is fully discussed.The pathway is not substantially altered when 2-benzamido-1-methoxy-1-phenylalkanes are cyclised.
