2549-31-7

Basic information

• Product Name: 4-methyl-2,5-diphenyl-1,3-oxazole
• CAS NO: 2549-31-7
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235.2805
• Mol File: 2549-31-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 380.9°C at 760 mmHg
• Flash Point: 159.4°C
• Density: 1.108g/cm³
• Vapor Pressure: 1.16E-05mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 4-methyl-2,5-diphenyl-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-2,5-diphenyl-1,3-oxazole(2549-31-7)
• EPA Substance Registry System: 4-methyl-2,5-diphenyl-1,3-oxazole(2549-31-7)

Safety Data

• Hazardous Substances Data: 2549-31-7(Hazardous Substances Data)

Upstream product

• 16735-29-8 N-(1-oxo-1-phenylpropan-2-yl)benzamide 
• 141118-65-2 2--1-(benzoyloxy)-1-phenyl-1-propene 
• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 
• 71-43-2 benzene 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 55-21-0 benzamide 
• 119-51-7 1-phenyl-1,2-propanedione 2-oxime 
• 93-55-0 1-phenyl-propan-1-one 
• 2198-64-3 N-Benzoylalanine 
• 93-97-0 benzoic acid anhydride 
• 126524-00-3 erythro (1S,2R)-1-phenyl-2-benzamido-1-propanol 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 100-46-9 benzylamine 
• 23031-08-5 benzoyl(pyridin-1-ium-1-yl)amide 

Downstream Products

• 19061-38-2 (9s,10s)-9,10-diphenyl-9,10-dihydro-9,10-epoxyanthracene 
• 15222-24-9 N,N-dibenzoyl acetamide 
• 126193-94-0 N-benzoyl-2-amino-2-methoxy-1-phenylpropanone 
• 126193-93-9 4,5-dimethoxy-2,5-diphenyl-4-methyl-2-oxazoline 
• 136885-78-4 6-Methyl-1,4-diphenyl-2,3,7-trioxa-5-aza-bicyclo[2.2.1]hept-5-ene 
• 126193-89-3 2,5-dimethoxy-2,4,5-triphenyl-3-oxazoline 
• 126193-89-3 2,5-dimethoxy-2,4,5-triphenyl-3-oxazoline 
• 114325-23-4 3-Benzoyl-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrrole-3,4-dicarboxylic acid dimethyl ester 
• 102536-98-1 4,5-Dimethyl-1,3-diphenyl-2-oxa-4-aza-bicyclo[3.2.0]hept-6-ene-6,7-dicarboxylic acid dimethyl ester 
• 136885-79-5 (3-Methyl-5-phenyl-3H-[1,2,4]dioxazol-3-yl)-phenyl-methanone 
• 126194-00-1 N-[1-Methyl-2-oxo-2-phenyl-eth-(Z)-ylidene]-benzamide 
• 4341-02-0 biphenyl-2,2'-dicarbonitrile 
• 781-43-1 9,10-dimethylanthracene 
• 56153-61-8 2-benzyl-benzonitrile 

Relevant articles and documents

NOVEL DEHYDROGENATION OF 2,5-DIARYLSUBSTITUTED Δ2-OXAZOLINES TO OXAZOLES

The dehydrogenation of various 2,5-diaryl substituted Δ2-oxazolines with either Br2/LiBr/CaCO3 (molar ratio 1.05 : 2 : 3) or CuBr2/LiBrCaCO3 (2 : 1 :3) in refluxing o-dichlorobenzene gives the corresponding oxazole in up to 87percent yield.Free radical benzylic bromination followed by dehydrobromination is the expected dehydrogenation mechanism.The successful application of the reagent combination for this transformation is in contrast to standard dehydrogenation reagents, including N-bromosuccinimide, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, chloranil, NiO2 and active γ-MnO2.

Alkynyl Thioethers in Gold-Catalyzed Annulations To Form Oxazoles

Non-oxidative, regioselective, and convergent access to densely functionalized oxazoles is realized in a functional-group tolerant manner using alkynyl thioethers. Sulfur-terminated alkynes provide access to reactivity previously requiring strong donor-substituted alkynes such as ynamides. Sulfur does not act in an analogous donor fashion in this gold-catalyzed reaction, thus leading to complementary regioselective outcomes and addressing the limitations of using ynamides.

One-pot preparation of 2,5-disubstituted and 2,4,5-trisubstituted oxazoles from aromatic ketones with molecular iodine, oxone, and trifluoromethanesulfonic acid in nitriles

Alkyl aryl ketones were successfully converted into the corresponding 2,5-disubstituted and 2,4,5-trisubstituted oxazoles in good to moderate yields in a one-pot manner, utilizing iodine, Oxone, and trifluoromethanesulfonic acid in nitriles under transition-metal-free conditions. The present method could be used for the preparation of Oxaprozin from benzyl phenyl ketone and succinonitrile. A possible reaction mechanism was proposed in which the key intermediates were α-iodoalkyl aryl ketones and α-iodosylalkyl aryl ketones.