66177-24-0

Basic information

• Product Name: 5-(benzyloxy)-1,3-benzodioxole
• Synonyms: 1,3-benzodioxole, 5-(phenylmethoxy)-
• CAS NO: 66177-24-0
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.2433
• Mol File: 66177-24-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 344.6°C at 760 mmHg
• Flash Point: 115.9°C
• Density: 1.231g/cm³
• Vapor Pressure: 0.00013mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 5-(benzyloxy)-1,3-benzodioxole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(benzyloxy)-1,3-benzodioxole(66177-24-0)
• EPA Substance Registry System: 5-(benzyloxy)-1,3-benzodioxole(66177-24-0)

Safety Data

• Hazardous Substances Data: 66177-24-0(Hazardous Substances Data)

Upstream product

• 533-31-3 Sesamol 
• 100-39-0 benzyl bromide 
• 120-57-0 piperonal 
• 100-44-7 benzyl chloride 

Relevant articles and documents

Facile and divergent optimization of chromazonarol enabled the identification of simplified drimane meroterpenoids as novel pharmaceutical leads

The diversity of drimane hydroquinones was significantly expanded by the facile construction of (+)-chromazonarol relevant natural products, isomers, and analogues for the discovery of new pharmaceutical leads. The structure-activity relationship of (+)-c

Diastereoselective synthesis of complex cis-hexahydroindanes by reductive alkylation

An efficient and operationally simple approach to complex cis-hexahydroindanes is reported. Upon Birch reduction of unprotected, C4-alkylated tetrahydroindanols and electrophilic trapping of the tetrasubstituted enolate, cis-fused products are formed with a new stereogenic quaternary carbon. The reaction is convergent, completely diastereoselective, and shows a broad scope with regard to the electrophile.

Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties

In this work, we reported the synthesis and evaluation of the analgesic, anti-inflammatory, and antipyretic properties of new 2-(6-nitro-benzo[1,3]dioxol-5-yloxy)-acetylhydrazone derivatives (3), designed exploring molecular hybridization and isosteric replacement approaches between nimesulide (1) and carbanalogue NAH series (2) developed at LASSBio. Target compounds were synthesized in very good yields exploiting abundant Brazilian natural product safrole (4) as starting material. The evaluation of the antinociceptive properties of this series led us to discover a new potent prototype of analgesic and antipyretic agent, that is, NAH derivative 3c, named LASSBio-891, which showed to be more potent than dipyrone used as standard.