66177-24-0Relevant articles and documents
Facile and divergent optimization of chromazonarol enabled the identification of simplified drimane meroterpenoids as novel pharmaceutical leads
Hu, Nvdan,Kong, Wenlong,Li, Shengkun,Song, Baoan,Wang, Xia
supporting information, (2021/10/16)
The diversity of drimane hydroquinones was significantly expanded by the facile construction of (+)-chromazonarol relevant natural products, isomers, and analogues for the discovery of new pharmaceutical leads. The structure-activity relationship of (+)-c
Synthesis of (±)-pterocarpin and its thia- and aza-analogues in a modular manner
Huang, Qingyun,Wang, Peng,Tian, Yu,Song, Ni,Ren, Sumei,Tao, Jiaxin,Hang, Kaini,Li, Ming
supporting information, p. 1385 - 1390 (2015/06/16)
Syntheses of racemic pterocarpin, its thia- and aza-pterocarpin have been achieved in a modular manner using sesamol iodide, diethyl malonate and 3-methoxyphenol, 3-methoxythiophenol and N-tosyl-3-methoxyaniline as building blocks. Copper-mediated Hurtley
Diastereoselective synthesis of complex cis-hexahydroindanes by reductive alkylation
Kaplan, Hilan Z.,Rendina, Victor L.,Kingsbury, Jason S.
, p. 4620 - 4626 (2013/06/27)
An efficient and operationally simple approach to complex cis-hexahydroindanes is reported. Upon Birch reduction of unprotected, C4-alkylated tetrahydroindanols and electrophilic trapping of the tetrasubstituted enolate, cis-fused products are formed with a new stereogenic quaternary carbon. The reaction is convergent, completely diastereoselective, and shows a broad scope with regard to the electrophile.
Total synthesis of 60-hydroxyjusticidin A
Xiong, Lu,Bi, Ming-Gang,Wu, Song,Tong, Yuan-Feng
scheme or table, p. 322 - 326 (2012/08/28)
The first total synthesis of 6′-hydroxyjusticidin A, isolated from Justicia procumbens L. with good inhibitory activity against cancer cells, has been accomplished. The structure was confirmed by 1H NMR, 13C NMR, and HR-ESI-MS. The key steps involved a Diels-Alder cycloaddition reaction and a reduction in NaBH4.
Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties
Bezerra-Netto, Heleno J.C.,Lacerda, Daniel I.,Miranda, Ana Luisa P.,Alves, Helio M.,Barreiro, Eliezer J.,Fraga, Carlos A.M.
, p. 7924 - 7935 (2007/10/03)
In this work, we reported the synthesis and evaluation of the analgesic, anti-inflammatory, and antipyretic properties of new 2-(6-nitro-benzo[1,3]dioxol-5-yloxy)-acetylhydrazone derivatives (3), designed exploring molecular hybridization and isosteric replacement approaches between nimesulide (1) and carbanalogue NAH series (2) developed at LASSBio. Target compounds were synthesized in very good yields exploiting abundant Brazilian natural product safrole (4) as starting material. The evaluation of the antinociceptive properties of this series led us to discover a new potent prototype of analgesic and antipyretic agent, that is, NAH derivative 3c, named LASSBio-891, which showed to be more potent than dipyrone used as standard.
Asymmetric total synthesis of (+)-pisatin, a phytoalexin from garden peas (Pisum sativum L.)
Pinard, Emmanuel,Gaudry, Michel,Henot, Frederic,Thellend, Annie
, p. 2739 - 2742 (2007/10/03)
A short asymmetric total synthesis of (+)-pisatin is described involving a Sharpless asymmetric dihydroxylation and an 'hydrogenative cyclisation' as key steps.
Synthesis of 4-Oxa-2-azapodophyllotoxin, a Novel Analog of the Antitumor Lignan Podophyllotoxin
Hitotsuyanagi, Yukio,Ichihara, Yoshitatsu,Takeya, Koichi,Itokawa, Hideji
, p. 9401 - 9402 (2007/10/02)
4-Oxa-2-azapodophyllotoxin (5) had been synthesized from sesamol (6). 5 showed significant activity against adriamycin-resistant P-388 leukemia cells.
Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-dihydro benzopyan-2H-one class having antiaggregatory properties
-
, (2008/06/13)
The present invention relates to novel benzopyranone aci-reductone compounds of the formula I wherein X and Y are selected from the group comprising H (except that X and Y are not both H, unless otherwise indicated) Cl or other halogen, OH, a straight or
New Sesamol Ethers as Pyrethrum Synergists
Devakumar, C.,Saxena, V. S.,Mukerjee, S. K.
, p. 725 - 730 (2007/10/02)
Several new methylenedioxyphenyl (MDP) ethers were synthesised from sesamol and methoxy substituted sesamols and screened as pyrethrum synergists.In general, the synergistic activity increased with the methoxyl substituents and decreased in the corresponding alkenyl analogs.The synergistic activity of alkyl ethers was found to vary with the alkyl chain, n-propyl ethers showing the maximum.In the case of alkenyl ethers, the activity followed the order γ,γ-dimethyl allyl > β-methallyl > allyl and showed no correlation between Rm and synergistic activity.
