66202-89-9

Downstream Products

• 15687-27-1 ibuprofen 
• 61566-34-5 (+/-)-ibuprofen methyl ester 
• 65961-37-7 (E)-1-(4-isobutylphenyl)-1-methoxy-1-propene 
• 115943-59-4 (Z)-1-(4-isobutylphenyl)-1-methoxy-1-propene 
• 59771-24-3 4-isobutylpropiophenone 
• 87498-05-3 1,1-dimethoxy-1-(4-isobutylphenyl)-2-iodopropane 

Relevant academic research and scientific papers

Process for oxidizing thallium (I) to thallium (III)

Thallium (l) alkanoate salts are oxidized to thallium (lll) salts in a liquid medium with a peroganic carboxylic acid in the presence of a reactive form of manganese or ruthenium.

Process for preparing arylalkanoic acid derivatives

2-Aryl-C3 to C6 -alkanoate esters are prepared economically by reacting an enol ether of an aryl alkyl ketone with a trivalent thallium salt in an organic solvent. The trivalent thallium ions can be regenerated by adding a peracid and a reactive form of manganese, ruthenium, cobalt, iridium, hafnium, osmium or neobium to oxidize monovalent thallium ions to the trivalent state, in a sequential, continuous or stoichiometric procedure. A continuous process using a Scheibel column is disclosed. The ester intermediate product is then converted to the corresponding 2-aryl-C3 - to C6 -alkanoic acid or salt thereof. The aryl group is selected so the resulting acid product will be a useful compound such as an anti-inflammatory, analgesic and anti-pyretic drug or agriculturally useful product. Examples of drug acids which can be made by this process include ibuprofen, flurbiprofen, fenoprofen and naproxen and the like.

Process for preparing arylalkanoic acid derivatives

2-Aryl-C3 to C6 -alkanoate esters are prepared economically by reacting an enol ether of an aryl alkyl ketone with a trivalent thallium salt in an organic solvent. The trivalent thallium ions can be regenerated by adding a peracid and a reactive form of manganese, ruthenium, cobalt, iridium, hafnium, osmium or neobium to oxidize monovalent thallium ions to the trivalent state, in a sequential, continuous or stoichiometric procedure. The ester intermediate product is then converted to the corresponding 2-aryl-C3 - to C6 -alkanoic acid or salt thereof. The aryl group is selected so the resulting acid product will be a useful compound such as anti-inflammatory, analgesic and anti-pyretic drug or agriculturally useful product. Examples of drug acids which can be made by this process include ibuprofen, flurbiprofen, fenoprofen and naproxen and the like.