66202-99-1 Usage
Chemical structure
A complex structure consisting of a benzofuran ring linked to a urea group and a diethylaminoethoxy side chain.
Benzofuran ring
A heterocyclic aromatic ring system that contributes to the compound's aromatic and ether-like nature.
Urea group
A functional group (-NH-CO-NH-) that adds to the compound's complexity and may be involved in hydrogen bonding.
Diethylaminoethoxy side chain
A side chain with a diethylamino group (-N(C2H5)2) attached to an ethoxy group (-O-CH2CH3), which may contribute to the compound's biological activity.
Methoxy groups
Several methoxy groups (-OCH3) are attached to the benzofuran ring, enhancing the compound's aromatic and ether-like properties.
Methyl group
A methyl group (-CH3) is present in the urea moiety, further adding to the compound's complexity.
Biological activity
Likely to have biological activity, particularly in areas related to central nervous system function, due to the presence of the diethylamino group.
Research and medicinal chemistry
May be used as a potential pharmacological agent in research and medicinal chemistry.
Solubility
The compound's solubility properties are not explicitly mentioned, but the presence of methoxy and diethylamino groups suggests it may be soluble in polar solvents like water or methanol.
Stability
The stability of the compound is not explicitly mentioned, but the presence of multiple functional groups suggests it may be sensitive to certain reaction conditions or degradation pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 66202-99-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,2,0 and 2 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 66202-99:
(7*6)+(6*6)+(5*2)+(4*0)+(3*2)+(2*9)+(1*9)=121
121 % 10 = 1
So 66202-99-1 is a valid CAS Registry Number.
66202-99-1Relevant academic research and scientific papers
Synthesis and Antiarrhythmic Activity of New Benzofuran Derivatives
Bourgery, Guy,Dostert, Philippe,Lacour, Alain,Langlois, Michel,Pourrias, Bernard,Tisne-Versailles, Jacky
, p. 159 - 167 (2007/10/02)
Various 5-aminobenzofuran derivatives were prepared from khellin and screened intravenously in the dog for their potential antiarrhythmic activity against ouabain-induced ventricular arrhythmia and in the Harris test.From systematic structural variations it was found that two methoxy groups in positions 4 and 7 on the benzofuran ring, a tertiary aminoethoxy side chain in position 6, and a N-methylurea group in position 5 led to the most active compounds.These were then tested orally in the Harris test in the dog.The two long-acting derivativesN--N'-methylurea (8j) and N--N'-methylurea (8m) showed advantages when compared to quinidine and diisopyramide and have been selected for further studies.
