66203-96-1

Usage

Uses

Used in Medicinal Chemistry:
1-(2-chloropropanoyl)piperidine is used as an intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(2-chloropropanoyl)piperidine is utilized as a reagent to facilitate the creation of various chemical entities, broadening the scope of chemical research and innovation.
Used in Research and Development:
1-(2-chloropropanoyl)piperidine is employed in research and development settings to explore its specific properties and investigate its potential uses, which may include the enhancement of existing pharmaceuticals or the invention of new compounds with therapeutic benefits.
It is crucial to handle 1-(2-chloropropanoyl)piperidine with caution and adhere to safety protocols due to its inherent hazards and risks, ensuring the safety of researchers and the integrity of the experimental process.

InChI:InChI=1/C8H14ClNO/c1-7(9)8(11)10-5-3-2-4-6-10/h7H,2-6H2,1H3

Upstream product

• 110-89-4 piperidine 
• 7623-09-8 2-chloropropionyl chloride 
• 766-09-6 1-ethyl-piperidine 
• 50893-53-3 carbonochloridic acid 1-chloro-ethyl ester 

Downstream Products

• 6091-44-7 piperidine hydrochloride 

Relevant academic research and scientific papers

Mild, powerful, and robust methods for esterification, amide formation, and thioesterification between acid chlorides and alcohols, amines, thiols, respectively

We developed two efficient practical methods for esterification, amide formation, and thioesterification between acid chlorides and alcohols, amines, thiols, respectively. The present mild and robust reaction was performed by two separate methods both by combining cheap and readily available amines, N-methylimidazole, and N,N,N′,N′-tetramethylethylenediamine (TMEDA). Method A uses catalytic N-methylimidazole and TMEDA with an equimolar amount of K2CO3, whereas Method B uses equimolar amounts of N-methylimidazole and TMEDA. The salient features are as follows. (i) With regard to reactivity, Method B was superior to Method A for esterification and thioesterification, whereas cost-effective Method A was superior to Method B for amide formation. (ii) Amide formation proceeded smoothly between acid chlorides and less nucleophilic and stereocongested amines such as 2,6-dichloroaniline. (iii) This protocol was applied to the successful synthesis of two agrochemicals, bromobutide and carpropamid.

A New Reagent for the Selective, High-Yield N-Dealkylation of Tertiary Amines: Improved Syntheses of Naltrexone and Nalbuphine

Secondary amine hydrochlorides are obtained in high yield by reaction of tertiary amines with α-chloroethyl chloroformate followed by warming the intermediate carbamate in methanol.