662165-78-8Relevant articles and documents
Compounds against inflammation and oxidative insult as potential agents for neurodegenerative disorders
Doulgkeris, Christos M.,Siskou, Ioanna C.,Xanthopoulou, Nikoletta,Lagouri, Vassiliki,Kravaritou, Constantina,Eleftheriou, Phaedra,Kourounakis, Panos N.,Rekka, Eleni A.
, p. 2280 - 2291 (2012/11/07)
Amides of proline, a feature encountered in nootropics, via the carboxylic group of ibuprofen, indomethacin, ketoprofen and naproxen were prepared. Proline carboxylic group was amidated or esterified with potential antioxidant or neuroprotective compounds. Proline was replaced by 4-hydroxyproline, 2-pipecolic acid or omitted, for investigating the contribution of structure to activity. Anti-inflammatory activity was determined, and selected compounds were examined for anti-dyslipidemic action, protection against brain ischaemia/reperfusion and brain penetration. Springer Science+Business Media, LLC 2011.
Use of S-proline as chiral auxiliary in α-alkylations of carboxylic acids
Srivastava, Stuti,Goswami, Lalit N.,Dikshit, Dinesh K.
, p. 2628 - 2631 (2007/10/03)
Use of S-proline as auxiliary in α-alkylations of carboxylic acids results in Se-face approach of the electrophile.