66255-85-4 Usage
Appearance
White solid with a slightly sweet odor (It is a white solid with a slightly sweet odor.)
Solubility
Insoluble in water (It is insoluble in water.)
Uses
Reagent in organic synthesis, intermediate in the production of pharmaceuticals and other fine chemicals (2,2-Dichlorobutyrophenone is commonly used as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals and other fine chemicals.)
Medical research
Potential use in the treatment of schizophrenia and other psychiatric disorders (It has been studied for its potential use in the treatment of schizophrenia and other psychiatric disorders.)
Pesticide development
Involvement in the development of insecticides (It is also known in the development of insecticides.)
Sedative effects
Mild sedative effects (The compound is also known to have some mild sedative effects.)
Handling precautions
Potentially hazardous substance (It is important to handle 2,2-Dichlorobutyrophenone with caution, as it is considered to be a potentially hazardous substance.)
Check Digit Verification of cas no
The CAS Registry Mumber 66255-85-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,2,5 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 66255-85:
(7*6)+(6*6)+(5*2)+(4*5)+(3*5)+(2*8)+(1*5)=144
144 % 10 = 4
So 66255-85-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H10Cl2O/c1-2-10(11,12)9(13)8-6-4-3-5-7-8/h3-7H,2H2,1H3
66255-85-4Relevant academic research and scientific papers
A Coupling Approach for the Generation of α,α-Bis(enolate) Equivalents: Regioselective Synthesis of gem-Difunctionalized Ketones
Iacono, Carmelo E.,Stephens, Thomas C.,Rajan, Teena S.,Pattison, Graham
supporting information, p. 2036 - 2040 (2018/02/19)
Regioselective α,α-difunctionalization adjacent to a ketone is a significant synthetic challenge. Here, we present a solution to this problem through the transition-metal-free coupling of esters with geminal bis(boron) compounds. This forms an α,α-bis(enolate) equivalent which can be trapped with electrophiles including alkyl halides and fluorinating agents. This presents an efficient, convergent synthetic strategy for the synthesis of unsymmetrical blocked ketones.
A Convenient Synthesis of 2,2-Dichloro-1-phenyl-1-alkanones and the Corresponding Imines
Kimpe, Norbert De,Coppens, Wim,Welch, John,Corte, Bart De
, p. 675 - 677 (2007/10/02)
N-(2,2-Dichloro-1-phenylalkylidene)isopropylamines were synthesized by deprotonation of N-(2,2-dichloro-1-phenylethylidene)isopropylamine by lithium diisopropylamide and reaction of the resulting 3,3-dichloro-1-azaallylic anion with alkyl bromides or iodi
