77664-50-7

Upstream product

• 6852-56-8 N-benzylideneisopropylamine 
• 2648-61-5 2,2-dichloroacetophenone 
• 75-31-0 isopropylamine 
• 78190-65-5 Isopropyl-(2,2,2-trichloro-1-phenyl-ethyl)-amine 

Downstream Products

• 130400-97-4 [5-Bromo-2,2-dichloro-5-methyl-1-phenyl-hex-(Z)-ylidene]-isopropyl-amine 
• 130400-99-6 N-(2,2-Dichloro-1-phenyl-1-pentylidene)isopropylamine 
• 130401-00-2 Isopropyl-[2,2,5-trichloro-1-phenyl-pent-(Z)-ylidene]-amine 
• 116670-48-5 [2,2-Dichloro-1-phenyl-prop-(Z)-ylidene]-isopropyl-amine 
• 130400-96-3 [2,2-Dichloro-1-phenyl-pent-4-en-(Z)-ylidene]-isopropyl-amine 
• 121059-30-1 2,2,5-Trichloro-1-phenyl-1-pentanone 
• 78401-43-1 2,2-dichloro-1-phenyl-4-penten-1-one 
• 1588-63-2 3,3-Dichloro-2-hydroxy-2-phenyloxolane 
• 66255-86-5 2,2-Dichloro-1-phenyl-1-pentanone 
• 66255-85-4 2,2-dichloro-1-phenyl-1-butanone 

Relevant academic research and scientific papers

Use of α,ω-Dichloroketimine Building Blocks for the Construction of 1-Azabicyclo[31.0]hexanes, Piperidines, Pyridines, Pyrroles, and Tetrahydroindoles

A variety of different N-[2-chloro-4-(chloromethyl)pent-4-enylidene]amines and N-(2,6-dichlorohex-4-enylidene)amines was prepared for the first time, and their reactivity as eligible building blocks for the synthesis of biologically relevant nitrogen-containing heterocyclic compounds was studied. In this way, a convenient entry into functionalized 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles, and tetrahydroindoles was developed, pointing to the broad synthetic flexibility of these dichlorinated imine substrates.

A Convenient Synthesis of 2,2-Dichloro-1-phenyl-1-alkanones and the Corresponding Imines

N-(2,2-Dichloro-1-phenylalkylidene)isopropylamines were synthesized by deprotonation of N-(2,2-dichloro-1-phenylethylidene)isopropylamine by lithium diisopropylamide and reaction of the resulting 3,3-dichloro-1-azaallylic anion with alkyl bromides or iodi

Reactions of 1-Trichloromethyl-substituted Amines with Potassium tert-Butoxide

The reaction of 1-trichloromethyl-substituted amines with tert-butoxide has been shown to provide important entries into a number of groups of functionalized amines, i.e., 2,2-dichlorovinylamines (which are also convertible into chloroynamines with a large excess of tert-butoxide), 2,2-dichloroenamines, N-(α-dichloromethylbenzylidene)amines and 2,2-dichloroaziridines.The formation of the products in individual cases depends upon the structure of the amine substrate.Keywords - 1-trichloromethyl-substituted amines; potassium tert-butoxide; 2-chloroynamines; 2,2-dichloroenamines; N-(α-dichloromethylbenzylidene)amines; 2,2-dichloroaziridines; elimination of hydrogen chloride