663-73-0

Usage

Uses

Used in Pharmaceutical Industry:
2,2,3,3-Tetrafluoropropionyl chloride is used as a reagent in the synthesis of pharmaceuticals for its ability to introduce fluorinated groups into drug molecules, which can enhance the drug's properties such as stability, solubility, and bioavailability.
Used in Agrochemical Industry:
In the agrochemical industry, 2,2,3,3-Tetrafluoropropionyl chloride is used as a precursor in the production of agrochemicals, where the introduction of fluorinated groups can improve the performance and selectivity of these compounds.
Used in Polymer Industry:
2,2,3,3-Tetrafluoropropionyl chloride is used as a monomer in the production of fluorinated polymers, which exhibit unique properties such as chemical resistance, thermal stability, and non-stick characteristics.
Used in Surfactant Industry:
In the surfactant industry, 2,2,3,3-Tetrafluoropropionyl chloride is used as a building block for the synthesis of fluorinated surfactants, which are known for their high surface activity, stability, and low foaming properties.
Due to its high reactivity, 2,2,3,3-Tetrafluoropropionyl chloride requires strict safety precautions during handling and storage to prevent severe skin and eye irritation, as well as potential harm from inhalation or ingestion.

InChI:InChI=1/C3HClF4O/c4-1(9)3(7,8)2(5)6/h2H

Upstream product

• 756-09-2 2,2,3,3-tetrafluoropropanoic acid 
• 98-88-4 benzoyl chloride 
• 2317-76-2 tri(2,2,3,3-tetrafluoropropyl) borate 

Downstream Products

• 1391943-74-0 (E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(dimethylamino)-4,4,5,5-tetrafluoro-3-oxopent-1-en-2-yl)isoxazole-4-carboxylate 
• 717-96-4 2,2,3,3-tetrafluoro-propionic acid anilide 

Relevant academic research and scientific papers

Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitabl

Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part by installing methylation marks on lysine 27 of histone 3. Dysregulation of PRC2 function correlates with certain malignancies and poor prognosis

PREPARATION OF 3-CHLOROTETRAFLUOROPROPIONYL CHLORIDE BY CHLORINATION OF THE ESTERS OF 2,2,3,3-TETRAFLUORO-1-PROPANOL

3-Chlorotetrafluoropropionyl chloride was synthesized by the photochemical chlorination of esters of the alcohol-telomer (n = 1) 2,2,3,3-tetrafluoro-1-propanol followed by thermal decomposition of the obtained α,α-chlorinated esters.

EINSTUFIGE HERSTELLUNG HALOGENIERTER CARBONSAUREFLUORIDE AUS DEN FREIEN SAUREN

The reaction of per- or polyhalogenated carboxylic acids with trifluoromethyl or difluorochloromethyl substituted aromatics takes place in the presence of Lewis-acid-catalysts and forms the corresponding acid fluorides in good to very good yields.

Thermal Decomposition of Some Perfluoro- and Polyfluorodiacyl Peroxides

Seven polyfluoroacyl peroxides were synthesized, some of them by a new procedure involving the direct interaction of an acyl fluoride with hydrogen peroxide.In the temperature range of 20-40 deg C, all these peroxides undergo first-order decomposition in dilute 1,1,2-trichloro-1,2,2-trifluoroethane (Freon-113) solutions (F-RF.Differing from other perfluoro or polyfluoro radicals, the perfluoro-α-isopropoxyethyl radicals (10) undergo substantial β scission to form perfluoroisopropyl radicals (11) during their lifetime.The ΔHexc. values for the perfluoroacyl peroxides are about 24 kcal mol-1, or about 5 kcal lower than that of the nonfluorinated diacyl peroxides (ca. 29 kcal mol-1).Apparently, the higher relative rates for 3 and 7 are caused by different factors.The latter peroxide (7) decomposes with a more favorable ΔSexc. term, whereas the former (3) decomposes with lower values of both ΔHexc. and ΔSexc..Thus, weakening of the peroxide bond by H bonding of the peroxide oxygen atom with the acidic ω-hydrogen atom seems to be implicated in the decomposition of 3.With a half-life of 81 min at 20 deg C, 3 may become a useful low-temperature initiator for free-radical reactions and polymerization.