756-09-2

Basic information

• Product Name: 3H-Tetrafluoropropionic acid
• Synonyms: FRENOCK;FLUPROPANATE;2,2,3,3-TETRAFLUOROPROPIONIC ACID;3H-TETRAFLUOROPROPIONIC ACID;2 2 3 3-TETRAFLUOROPROPIONIC ACID 96%;flupropanate (bsi, draft e-iso, draft f-iso);2,2,3,3-tetrafluoropropanoic acid;2,2,3,3-Tetrafluoropropionicacid97%
• CAS NO: 756-09-2
• Molecular Formula: C₃H₂F₄O₂
• Molecular Weight: 146.04
• EINECS: 212-049-7
• Mol File: 756-09-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 133-134°C
• Flash Point: 133-134°C
• Appearance: /
• Density: 1,563 g/cm3
• Vapor Pressure: 3.47mmHg at 25°C
• Refractive Index: 1.321
• Storage Temp.: 0-6°C
• Solubility: Chloroform (Slightly), Methanol
• PKA: 0.56±0.10(Predicted)
• Water Solubility: Sparingly soluble in water.
• CAS DataBase Reference: 3H-Tetrafluoropropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Tetrafluoropropionic acid(756-09-2)
• EPA Substance Registry System: 3H-Tetrafluoropropionic acid(756-09-2)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 756-09-2(Hazardous Substances Data)

Usage

Uses

3H-Tetrafluoropropionic acid is used to produce 2,2,3,3-tetrafluoro-propionyl chloride. This reaction will need reagent benzotrichloride.

InChI:InChI=1/C3H2F4O2/c4-1(5)3(6,7)2(8)9/h1H,(H,8,9)/p-1

Upstream product

• 76-37-9 2,2,3,3-tetrafluoropropanol 
• 66-71-7 1,10-Phenanthroline 
• 52-68-6 trichlorfon 
• 337-83-7 2,2,3,3-tetrafluoropropionic acid anhydride 
• 215858-32-5 2,2,3,3-tetrafluoropropionaldehyde hydrate 
• 129657-55-2 ethyl (4,4,5,5-tetrafluoro-3-oxy-3-tert-butylperoxy)pentanoate 
• 116-14-3 polytetrafluoroethylene 
• 143-33-9 sodium cyanide 

Downstream Products

• 2252-84-8 HFC-227ca 
• 1893-38-5 methyl 2,2,3,3-tetrafluoropropionate 
• 663-73-0 α,α,β,β-tetrafluoropropionic acid chloride 
• 1579-57-3 2,2,3,3-tetrafluoro-propionic acid-(4-chloro-anilide) 
• 337-83-7 2,2,3,3-tetrafluoropropionic acid anhydride 
• 661-82-5 3-Chlor-2,2,3,3-tetrafluor-propionsaeure 

Relevant articles and documents

PYRIMIDONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS

The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

Polyfluoroalkoxy phosphonic and phosphinic acid derivatives: II. Reversible esterase inhibitors

Polyfluoroalkyl esters of phosphoric, alkylphosphonic and 1-hydroxypolyfluoroalkylphosphonic acids exhibited significant antiesterase activity against various esterases of animal and microbial origin. Moreover, with some compounds reversible inhibition of enzymes was observed due to the specific influence of hydrophobic fragments of the target products.

Method for preparing α-substituted ω-hydroperfluoroalkanes

A method for the preparation of α-substituted ω-dihydroperluoroalkane derivatives of the general formula H(CF2 CF2)n R wherein R=H or COOH, and n=1-10 is characterized by oxidizing α, α, ω-trihydroperfluoroalcohols with an oxygen gas or an oxygen-containing gas in the presence of a homogeneous copper catalyst and an alkaline agent in an organic solvent with subsequent isolation of the desired product.