6630-85-9Relevant academic research and scientific papers
Developments in Meyers' lactamization methodology: En route to Bi(hetero)aryl structures with defined axial chirality
Postikova, Svetlana,Sabbah, Mohamad,Wightman, Daniel,Nguyen, Ich Tuan,Sanselme, Morgane,Besson, Thierry,Briere, Jean-Francois,Oudeyer, Sylvain,Levacher, Vincent
supporting information, p. 8191 - 8197 (2013/09/12)
Highly atroposelective Meyers' lactamization promoted by pivalic acid under microwave irradiation is reported which allows the construction of nonracemic substituted-dibenzo(di)azepine derivatives through a center to axial chirality transfer principle, controlling the otherwise configurationally labile biaryl axis. This approach provides a straightforward entry to enantioenriched analogues of biorelevant architectures.
Therapeutic and diagnostic ligand systems comprising transport molecule binding properties and medicaments containing the same
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, (2008/06/13)
The invention relates to transport molecule binding ligand compounds which comprise a therapeutically and/or diagnostically active substance and a carrier molecule-affine substance with a high association constant to the carrier molecule. The invention also relates to medicaments containing these ligand compounds and to diagnostic kits.
