66307-43-5

Basic information

• Product Name: 1-Phenoxy-3-(4-phenylpiperazino)-2-propanol
• Synonyms: 1-Phenoxy-3-(4-phenylpiperazino)-2-propanol;α-(Phenoxymethyl)-4-phenyl-1-piperazineethanol
• CAS NO: 66307-43-5
• Molecular Formula: C₁₉H₂₄N₂O₂
• Molecular Weight: 312.4061
• Mol File: 66307-43-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 498°Cat760mmHg
• Flash Point: 255°C
• Appearance: /
• Density: 1.143g/cm³
• Vapor Pressure: 9.8E-11mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 1-Phenoxy-3-(4-phenylpiperazino)-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenoxy-3-(4-phenylpiperazino)-2-propanol(66307-43-5)
• EPA Substance Registry System: 1-Phenoxy-3-(4-phenylpiperazino)-2-propanol(66307-43-5)

Safety Data

• Hazardous Substances Data: 66307-43-5(Hazardous Substances Data)

Usage

Properties

Antibacterial and antifungal

Uses

Antiseptic and disinfectant in personal care and household products (e.g. hand soaps, mouthwashes, surface cleaners)

Mechanism of Action

Disrupts cell membranes of bacteria and fungi, leading to their death

Safety and Efficacy

Extensively studied and considered relatively low-risk when used as directed

Regulatory Approvals

Approved by U.S. Food and Drug Administration and the European Chemicals Agency

InChI:InChI=1/C19H24N2O2/c22-18(16-23-19-9-5-2-6-10-19)15-20-11-13-21(14-12-20)17-7-3-1-4-8-17/h1-10,18,22H,11-16H2

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 106-89-8 epichlorohydrin 
• 108-95-2 phenol 
• 122-60-1 Phenyl glycidyl ether 

Relevant articles and documents

The Synthesis and Antiallergy Activity of 1-(Aryloxy)-4-(4-arylpiperazinyl)-2-butanol Derivatives

A series of 1-(aryloxy)-4-(4-arylpiperazinyl)-2-butanol derivatives were prepared and evaluated for antiallergy activity in the passive foot anaphylaxis (PFA) assay in rats.Twenty-seven derivatives had activity equal to or greater than the parent, α-(phen

3-Tertiary amino-1-aryloxy- or aryl-propanes and -propan -2-ols and some related compounds

The synthesis and pharmacological activity of some 3 tertiary amino 1 aryloxy or 1 aryl, 1 thiophenoxy and 1 anilino propan 2 ols and propanes, particularly those derived from N phenylpiperazines are described. Effect of substituents (nature/position) on the phenyl ring, the phenoxy ring as well as alteration in the hydroxylic function vis a vis the structure activity relationships (SAR) are discussed. In general, the 1 aryloxy compounds have hypotensive activity this being more pronounced in those carrying an o substituent on the phenyl ring, while m and p substituted derivatives have their effect primarily on the CNS. Variations in the phenoxy moiety do not significantly alter the intrinsic activity. The 1 aryl compounds, on the other hand, have significant CNS activity, which is markedly affected by the substituents on the 1 aryl residue.