6631-22-7Relevant articles and documents
Preparation and crystal structural study of a novel coordinated polymer [HgI2(4-bped)2] (bped = bis(4-pyridyl)ethylene diamine)
Liang, Yu,Zhao, Fukai,Wang, Qingli,Niu, Yunyin
, p. 763 - 766 (2011)
A novel coordinated polymer [HgI2(4-bped)2] was synthesized through the reaction of bis(4-pyridyl)ethylene diamine and HgI 2 in mixed MeOH-THF (5:2). The crystal structural analysis indicated that the complex crystallized in a monoclinic space group P21/c, a = 10.8392(12), b = 19.841(2), c = 8.8279(10), β = 95.452(2), V = 1889.9(4) A3, Z = 4. The complex possessed a novel three-dimensional supramolecular framework formed by hydrogen bonds among repeating [HgI 2(4-bped)]2 dimeric units.
Structural diversity and variable temperature magnetic properties in copper dimethylmalonate coordination polymers containing dipyridyl-type coligands
Kalman, Colton J.,Stone, Brandon S.,LaDuca, Robert L.
, p. 674 - 682 (2019)
Four copper dimethylmalonate (dmmal) phases containing long-spanning dipyridyl coligands have been prepared and structurally characterized by single-crystal X-ray diffraction. {[Cu2(dmmal)2(edin)(H2O)2]·3H2O}n (1, edin = N,N′-(ethane-1,2-diyl)diisonicotinamide) and {[Cu2(dmmal)2(bdin)(H2O)2]·2H2O}n (2, bdin = N,N′-(butane-1,4-diyl)diisonicotinamide) both show (6,3) herringbone layers constructed from the edin pillaring of [Cu(H2O)(dmmal)]n chain motifs, that feature embedded equatorial-equatorial bridged {Cu(OCO)}n chains. [Cu2(dmmal)2(bpmp)]n (3, bpmp = bis(4-pyridylmethyl)piperazine) shows a decorated (4,4) grid topology built from bpmp pillared [Cu2(dmmal)2]n ribbon motifs, that feature embedded {Cu2(OCO)4} paddlewheel dimeric units. [Cu2(dmmal)2(bpfp)]n (4, bpfp = bis(4-pyridylformyl)piperazine) shows a 5-connected non-interpenetrated 3D 4466 sqp topology, formed from the bpfp pillaring of rectangular equatorial-equatorial bridged [Cu2(dmmal)2]n layers. Variable temperature magnetic studies were carried out on 1, 2 and 4, indicating predominant ferromagnetic superexchange within their equatorial-equatorial {Cu(OCO)}n chain motifs.
Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; Their synthesis, binding kinetics and cytotoxicity
Brown, Sarah D.,Trotter, Katherine D.,Sutcliffe, Oliver B.,Plumb, Jane A.,Waddell, Bruce,Briggs, Naomi E. B.,Wheate, Nial J.
, p. 11330 - 11339 (2013/06/26)
Picoplatin is a sterically hindered mononuclear platinum drug undergoing clinical trials. The 2-methylpyridine ring provides steric hindrance to the drug, preventing attack from biological nucleophiles. BBR3464 is a trinuclear platinum drug which was recently in Phase II clinical trials, and is highly cytotoxic both in vitro and in vivo; it derives this activity through the flexible adducts it forms with DNA. In this work we sought to combine the properties of both drugs to synthesise a family of sterically hindered, dinuclear platinum complexes as potential anticancer agents. The bis-pyridyl-based ligands were synthesised through a peptide coupling reaction using diaminoalkanes of differing lengths (n = 2, 4 or 8) and 4-carboxypyridine or 2-methyl-4-carboxypyridine. The resultant dinuclear platinum complexes were synthesised by reacting two equivalents of transplatin or mono-aquated transplatin to each ligand, followed by purification by precipitation with acetone. The unprotected complexes react faster with 5′-guanosine monophosphate (drug to nucleotide ratio 1:2; t1/2 = 2 h), glutathione (1:10, t1/2 = 55 min) and human serum albumin (HSA) (1:1, t 1/2 = 24 h) compared to their hindered, protected equivalents (5′-guanosine monophosphate, t1/2 = 3.5 h; glutathione = 1.7 h; HSA, t1/2 = 110 h). The complexes were tested for in vitro cytotoxicity in the A2780 and A2780/cp70 ovarian cancer cell line. The unprotected platinum complexes were more cytotoxic than their protected derivatives, but none of the complexes were able to overcome resistance. The results provide important proof-of-concept for the development of a larger family of sterically hindered multinuclear-based platinum complexes.
