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• 55-22-1 pyridine-4-carboxylic acid 
• 107-15-3 ethylenediamine 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 39178-35-3 isonicotinoyl chloride hydrochloride 

Relevant academic research and scientific papers

Preparation and crystal structural study of a novel coordinated polymer [HgI2(4-bped)2] (bped = bis(4-pyridyl)ethylene diamine)

A novel coordinated polymer [HgI2(4-bped)2] was synthesized through the reaction of bis(4-pyridyl)ethylene diamine and HgI 2 in mixed MeOH-THF (5:2). The crystal structural analysis indicated that the complex crystallized in a monoclinic space group P21/c, a = 10.8392(12), b = 19.841(2), c = 8.8279(10), β = 95.452(2), V = 1889.9(4) A3, Z = 4. The complex possessed a novel three-dimensional supramolecular framework formed by hydrogen bonds among repeating [HgI 2(4-bped)]2 dimeric units.

Structural diversity in cobalt camphorate coordination polymers with flexible dipyridylamide ligands including looped layers and self-penetrated topologies

Hydrothermal reaction of cobalt nitrate, D-camphoric acid, and flexible dipyridylamide ligands afforded a series of coordination polymers with diverse structural topologies, as characterized by single crystal X-ray diffraction.{[Co2(DL-cam)2(edn)]·2H2O}n (1, edn = N,N′-(ethane-1,2-diyl)dinicotinamide) shows a 3D 41263 pcu net built from straight-pillaring of {Co2(OCO)4} paddlewheel dimer-based [Co2(DL-cam)2]n layer motifs. In contrast, [Co(D-cam)(edin)]n (2, edin = N,N′-(ethane-1,2-diyl)diisonicotinamide) manifests a two-fold parallel interpenetrated looped layer topology. {[Co2(DL-cam)2(bdin)]·2H2O}n (3, bdin = N,N′-(butane-1,4-diyl)diisonicotinamide) displays a very rare 3D 446108 roa self-penetrated net built from cross-pillaring of {Co2(OCO)4} paddlewheel dimer-based [Co2(DL-cam)2]n layer motifs, as does {[Co2(DL-cam)2(pedin)]·2H2O}n (4, pedin = N,N′-(pentane-1,5-diyl)diisonicotinamide). [Co(D-cam)(hdin)]n (5, hdin = N,N′-(hexane-1,6-diyl)diisonicotinamide) shows a simple stacked system of sawtooth (4,4) grid motifs. Thermal properties are discussed herein.

Structural diversity and variable temperature magnetic properties in copper dimethylmalonate coordination polymers containing dipyridyl-type coligands

Four copper dimethylmalonate (dmmal) phases containing long-spanning dipyridyl coligands have been prepared and structurally characterized by single-crystal X-ray diffraction. {[Cu2(dmmal)2(edin)(H2O)2]·3H2O}n (1, edin = N,N′-(ethane-1,2-diyl)diisonicotinamide) and {[Cu2(dmmal)2(bdin)(H2O)2]·2H2O}n (2, bdin = N,N′-(butane-1,4-diyl)diisonicotinamide) both show (6,3) herringbone layers constructed from the edin pillaring of [Cu(H2O)(dmmal)]n chain motifs, that feature embedded equatorial-equatorial bridged {Cu(OCO)}n chains. [Cu2(dmmal)2(bpmp)]n (3, bpmp = bis(4-pyridylmethyl)piperazine) shows a decorated (4,4) grid topology built from bpmp pillared [Cu2(dmmal)2]n ribbon motifs, that feature embedded {Cu2(OCO)4} paddlewheel dimeric units. [Cu2(dmmal)2(bpfp)]n (4, bpfp = bis(4-pyridylformyl)piperazine) shows a 5-connected non-interpenetrated 3D 4466 sqp topology, formed from the bpfp pillaring of rectangular equatorial-equatorial bridged [Cu2(dmmal)2]n layers. Variable temperature magnetic studies were carried out on 1, 2 and 4, indicating predominant ferromagnetic superexchange within their equatorial-equatorial {Cu(OCO)}n chain motifs.

Divergent topologies in luminescent and nitrobenzene-detecting zinc diphenate coordination polymers with flexible dipyridylamide ligands

Hydrothermal reaction of zinc nitrate, diphenic acid (H2dip), and one of the dipyridylamide ligands N,N′-(hexane-1,6-diyl)diisonicotinamide (hdin), N,N′-(pentane-1,5-diyl)diisonicotinamide (pedin), N,N′-(butane-1,4-diyl)diisonicotinamide (bdin), or N,N′-(ethane–1,2-diyl)diisonicotinamide (edin) resulted in coordination polymers whose dimensionalities depend on the aliphatic tether length within the coligand and the amount of base used in the synthesis. The five new phases were characterized by single crystal X-ray diffraction. {[Zn(dip)(hdin)]·2.5H2O}n (1) and {[Zn(dip)(pedin)]·2.5H2O}n (2) both possess undulating 2D coordination polymer layers with [Zn(dip)]n chains spanned by looped dipyridylamine ligands into a 2,4-connected self-penetrated (6)(648.10) topology. [Zn(dipH)2(bdin)]n (3) manifests a 1-D zig-zag chain topology, while {[Zn3(dip)3(bdin)3]·13H2O}n (4) and {[Zn(dip)(edin)]·3H2O}n (5) manifest helical substructures linked into a rare two-fold interpenetrated 6482 nbo topology. Thermal and luminescent properties were also probed; compounds 1–5 showed ability to detect nitrobenzene in ethanol suspension with the 3D derivatives 4 and 5 manifesting the best “turn-off” luminescence quenching behavior.

Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; Their synthesis, binding kinetics and cytotoxicity

Picoplatin is a sterically hindered mononuclear platinum drug undergoing clinical trials. The 2-methylpyridine ring provides steric hindrance to the drug, preventing attack from biological nucleophiles. BBR3464 is a trinuclear platinum drug which was recently in Phase II clinical trials, and is highly cytotoxic both in vitro and in vivo; it derives this activity through the flexible adducts it forms with DNA. In this work we sought to combine the properties of both drugs to synthesise a family of sterically hindered, dinuclear platinum complexes as potential anticancer agents. The bis-pyridyl-based ligands were synthesised through a peptide coupling reaction using diaminoalkanes of differing lengths (n = 2, 4 or 8) and 4-carboxypyridine or 2-methyl-4-carboxypyridine. The resultant dinuclear platinum complexes were synthesised by reacting two equivalents of transplatin or mono-aquated transplatin to each ligand, followed by purification by precipitation with acetone. The unprotected complexes react faster with 5′-guanosine monophosphate (drug to nucleotide ratio 1:2; t1/2 = 2 h), glutathione (1:10, t1/2 = 55 min) and human serum albumin (HSA) (1:1, t 1/2 = 24 h) compared to their hindered, protected equivalents (5′-guanosine monophosphate, t1/2 = 3.5 h; glutathione = 1.7 h; HSA, t1/2 = 110 h). The complexes were tested for in vitro cytotoxicity in the A2780 and A2780/cp70 ovarian cancer cell line. The unprotected platinum complexes were more cytotoxic than their protected derivatives, but none of the complexes were able to overcome resistance. The results provide important proof-of-concept for the development of a larger family of sterically hindered multinuclear-based platinum complexes.