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Upstream product

• 85302-07-4 2-(dimethylaminomethylene)cyclohexane-1,3-dione 
• 504-02-9 1,3-cylohexanedione 
• 98-16-8 3-trifluoromethylaniline 
• 25625-57-4 2-bromo-N-(3′-(trifluoromethyl)phenyl)acetamide 
• 165283-98-7 5-oxo-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives

Forty seven thieno[2,3-b]pyridines-2-carboxamides, furo[2,3-b]pyridines-2-carboxamides and tetrahydrothieno[2,3-b]quinolones-2-carboxamides derivatives were synthesized and tested for their antiproliferative activity against the NCI-60 cell lines. The 5-keto-tetrahydrothieno[2,3-b]quinolones-2-carboxamides (series 17) were found to have the greatest activity, with the compound containing a 3-methoxyphenylcarboxamide (compound 17d) being the most active, with GI50values in the low nanomolar range against a range of cell lines, in particular the melanoma cell line MDA-MD-435 (GI50- 23 nM) and the breast cancer cell line MDA-MB-468 (GI50- 46 nM). Molecular modelling of series 17 against phosphoinositide specific-phospholipase C reveals that the side chains of the amino acids His356, Glu341, Arg549 and Lys438 are involved in hydrogen bonding with the ligands as well as a lipophilic pocket is occupied by the phenyl carboxamide moiety.