6321-12-6

Basic information

• Product Name: 2-(4-nitrophenyl)acetamide
• CAS NO: 6321-12-6
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.1607
• Mol File: 6321-12-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 432°C at 760 mmHg
• Flash Point: 215°C
• Density: 1.335g/cm³
• Vapor Pressure: 1.15E-07mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-(4-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)acetamide(6321-12-6)
• EPA Substance Registry System: 2-(4-nitrophenyl)acetamide(6321-12-6)

Safety Data

• Hazardous Substances Data: 6321-12-6(Hazardous Substances Data)

Usage

General Description

2-(4-nitrophenyl)acetamide is a chemical compound with the molecular formula C8H8N2O3. It consists of a 4-nitrophenyl group attached to an acetamide group. 2-(4-nitrophenyl)acetamide is commonly used in organic synthesis and pharmaceutical research as a building block for the creation of various pharmaceuticals and bioactive compounds. Its unique structure and properties make it a valuable tool for chemists and researchers in the development of new drugs and treatments for various medical conditions. Additionally, it is important to handle this compound with care due to its potential for toxicity and adverse effects on human health.

Upstream product

• 555-21-5 4-Nitrophenylacetonitrile 
• 103-81-1 Benzeneacetamide 
• 24954-67-4 2-(p-nitrophenyl)ethylamine 
• 5445-26-1 ETHYL 4-NITROPHENYLACETATE 
• 24424-99-5 di-tert-butyl dicarbonate 
• 104-03-0 4-nitrobenzeneacetic acid 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 2945-08-6 methyl (4-nitrophenyl)acetate 
• 7664-41-7 ammonia 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 1641-36-7 n-butylammonium acetate 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 102541-39-9 (4-nitro-phenyl)-acetic acid-(2,2,2-trichloro-1-hydroxy-ethylamide) 
• 6633-76-7 2-(4-aminophenyl)acetamide 
• 95435-01-1 2-(4-nitro-phenyl)-5-oxo-3,5-diphenyl-valeric acid amide 
• 38426-03-8 1-(2-Chloro-acetyl)-3-[2-(4-nitro-phenyl)-acetyl]-urea 
• 38425-99-9 1-(3-Chloro-propionyl)-3-[2-(4-nitro-phenyl)-acetyl]-urea 
• 88078-20-0 4-methyl-3-(p-nitrophenyl)-2,3,3a,4,9,9a-hexahydro-1H-pyrrolo(2,3-b)quinoxalin-2-one 
• 110842-02-9 3,4-Bis-(4-nitro-phenyl)-1,5-dihydro-pyrrol-2-one 
• 84863-96-7 3-Hydroxy-4-(4-nitro-phenyl)-pyrrole-2,5-dione 
• 110841-99-1 3-(4-Nitro-phenyl)-4-phenyl-1,5-dihydro-pyrrol-2-one 
• 110842-00-7 4-(4-Ethoxy-phenyl)-3-(4-nitro-phenyl)-1,5-dihydro-pyrrol-2-one 
• 110842-01-8 4-(4-Amino-phenyl)-3-(4-nitro-phenyl)-1,5-dihydro-pyrrol-2-one 

Relevant articles and documents

Aerobic oxidation of primary amines to amides catalyzed by an annulated mesoionic carbene (MIC) stabilized Ru complex

Catalytic aerobic oxidation of primary amines to the amides, using the precatalyst [Ru(COD)(L1)Br2] (1) bearing an annulated π-conjugated imidazo[1,2-a][1,8]naphthyridine-based mesoionic carbene ligand L1, is disclosed. This catalytic protocol is distinguished by its high activity and selectivity, wide substrate scope and modest reaction conditions. A variety of primary amines, RCH2NH2 (R = aliphatic, aromatic and heteroaromatic), are converted to the corresponding amides using ambient air as an oxidant in the presence of a sub-stoichiometric amount of KOtBu in tBuOH. A set of control experiments, Hammett relationships, kinetic studies and DFT calculations are undertaken to divulge mechanistic details of the amine oxidation using 1. The catalytic reaction involves abstraction of two amine protons and two benzylic hydrogen atoms of the metal-bound primary amine by the oxo and hydroxo ligands, respectively. A β-hydride transfer step for the benzylic C-H bond cleavage is not supported by Hammett studies. The nitrile generated by the catalytic oxidation undergoes hydration to afford the amide as the final product. This journal is

Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides to Form Nitriles

A palladium(II) catalyst, in the presence of Selectfluor, enables the efficient and chemoselective transformation of primary amides into nitriles. The amides can be attached to aromatic rings, heteroaromatic rings, or aliphatic side chains, and the reactions tolerate steric bulk and electronic modification. Dehydration of a peptaibol containing three glutamine groups afforded structure-activity relationships for each glutamine residue. Thus, this dehydration can act similarly to an alanine scan for glutamines via synthetic mutation.

HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF

Provided herein are novel heteroaromatic derivatives, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a prodrug, a pharmaceutically acceptable salt or a prodrug thereof, and pharmaceutical compositions containing such compounds. Also provided herein are uses of such compounds or pharmaceutical compositions thereof in the manufacture of a medicament for treating respiratory diseases, especially chronic obstructive pulmonary disease (COPD).