66336-02-5

Usage

Functional groups

Nitro-substituted pyridin-2(1H)-one, ethyl group on the nitrogen atom

Chemical structure

A pyridine ring with a nitro group at the 5th position, a carbonyl group at the 2nd position, and an ethyl group attached to the nitrogen atom

Pharmaceutical research and development

Building block for the synthesis of various bioactive molecules and drugs

Agrochemicals

Intermediate in the production of agrochemicals

Dyes

Intermediate in the production of dyes

Potential uses

Development of new medicines, manufacturing of various industrially important compounds

Upstream product

• 5418-51-9 5-nitro-2-pyridone 
• 75-03-6 ethyl iodide 
• 5446-92-4 2-methoxy-5-nitropyridine 
• 64-67-5 diethyl sulfate 
• 5418-51-9 5-nitro-2-hydroxypyridine 

Downstream Products

• 74937-42-1 3-bromo-1-ethyl-5-nitro-2(1H)-pyridinone 
• 1016710-71-6 5-amino-1-ethylpyridin-2(1H)-one 
• 1201916-93-9 C₃₀H₃₄Cl₂FN₅O₇ 
• 1201916-63-3 {6-amino-5-[(2,6-dichloro-3-fluorophenyl)ethoxy]-pyridazin-3-yl}-N-(1-ethyl-6-oxo-1,6-dihydro-pyridin-3-yl)carboxamide 
• 4548-45-2 2-chloro-5-nitropyridine 

Relevant academic research and scientific papers

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS

The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against c-Met and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

Microwave assisted rapid preparation of N-alkyl-2-pyridones under neutral conditions by Hilbert-Johnson reaction

The reactions of 2-methoxypyridine with haloalkanes without solvent and catalyst under microwave irradiation (100-200 °C, 5 min) yielded the corresponding N-alkyl-2(1H)-pyridones in good to moderate yields. However, the reactions were sensitive to length of haloalkanes. In contrast, the reactions of 2-alkoxypyridines with corresponding iodoalkanes under microwave irradiation (150 °C) proceeded rapidly without catalyst and solvent, and were complete within 5 min to afford N-alkyl-2(1H)-pyridones in good to excellent yields. The Japan Institute of Heterocyclic Chemistry.

SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS

Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

Hilbert-Johnson reaction under high pressure: A facile preparation of 2-pyridones

For the first time, a facile synthesis of 2-pyridones utilizing a classical Hilbert-Johnson reaction of 2-methoxypyridines with haloalkanes under high pressure has been achieved. The reactions were sensitive to steric hindrance of haloalkanes.