66346-83-6

Usage

Uses

Used in Pharmaceutical Research:
6-Chloropyridazine-3-carboxamide is utilized as a research compound for its potential antitumor, antifungal, and antibacterial activities, contributing to the development of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 6-Chloropyridazine-3-carboxamide is employed as a key intermediate, facilitating the creation of various complex organic molecules.
Used in Inflammation and Autoimmune Disease Treatment:
6-Chloropyridazine-3-carboxamide is used as an inhibitor of Janus kinase enzymes, which are involved in inflammatory and autoimmune diseases, offering a potential therapeutic approach for conditions related to these enzyme activities.
Used in Medicinal Chemistry:
Due to its unique molecular structure and diverse pharmacological properties, 6-Chloropyridazine-3-carboxamide is an important target for further research and development in medicinal chemistry, with the aim of discovering new drugs with improved efficacy and safety profiles.

InChI:InChI=1/C5H4ClN3O/c6-4-2-1-3(5(7)10)8-9-4/h1-2H,(H2,7,10)

Upstream product

• 75680-92-1 6-chloro-3-pyridazinecarboxylic acid ethyl ester 
• 65202-50-8 methyl 6-chloro-3-pyridazinecarboxylate 
• 6531-04-0 6-chloro-pyridazine-3-carbonyl chloride 
• 63001-31-0 ethyl 1,6-dihydro-6-oxopyridazine-3-carboxylate 
• 98995-11-0 6-chloro-pyridazine-3-carboxylic acid butyl ester 
• 37972-69-3 6-oxo-1,6-dihydropyridazine-3-carboxylic acid 

Downstream Products

• 3614-47-9 hydracarbazine 
• 89280-46-6 3-hydrazinopyridazine-6-carboxylic acid hydrazide 
• 142674-93-9 6-Benzylamino-pyridazine-3-carboxylic acid amide 
• 35857-89-7 6-chloropyridazine-3-carbonitrile 
• 142054-71-5 6-Propylamino-pyridazine-3-carboxylic acid methyl ester 
• 142054-70-4 6-Benzylamino-pyridazine-3-carboxylic acid methyl ester 
• 142054-67-9 6-butylamino-3-pyridazinecarboxamide 
• 187229-76-1 6-[N-(5-Chloro-2-(2-methylprop-2-en-1-yloxy)benzyl)-N-ethylamino]pyridazine-3-carboxamide 
• 177758-69-9 6-[N-(2-benzyloxy-5-bromobenzyl)-N-ethylamino]pyridazine-3-carboxamide 
• 49542-03-2 3-Hydrazino-6-cyano-pyridazin 
• 69579-17-5 3-[(6-carbamoyl-pyridazin-3-yl)-hydrazono]-butyric acid tert-butyl ester 
• 944808-50-8 C₁₆H₁₈ClN₅O₂ 

Relevant academic research and scientific papers

CONDENSED PYRIDINE COMPOUND

The present invention provides a compound having excellent JAK3 inhibitory activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases, inflammatory diseases, and allergic diseases. As a result of investigations with respect to novel condensed heterocyclic derivatives, the inventors have verified that a condensed pyridine compound has excellent JAK3 inhibitory activity, thereby completing the present invention. More specifically, it has been verified that since the compound according to the present invention has inhibitory activity against JAK3, the compound is useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transduction (e.g., rejection during live organ/tissue transplantation, autoimmune diseases, asthma, atopic dermatitis, rheumatism, psoriasis and atherosclerotic disease), or diseases caused by abnormal cytokine signal transduction (e.g., cancer and leukemia).

Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors

Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids. Studies with SCD1 knockout mice have established that these animals are lean and protected from leptin

Aromatic amine compounds that antagonize the pain enhancing effects of prostaglandins

PCT No. PCT/GB96/01443 Sec. 371 Date Dec. 16, 1997 Sec. 102(e) Date Dec. 16, 1997 PCT Filed Jun. 17, 1996 PCT Pub. No. WO97/00864 PCT Pub. Date Jan. 9, 1997Compounds antagonistic of the pain enhancing effects of prostaglandins are disclosed. The compounds

Aromatic compounds and pharmaceutical compositions containing them

The invention relates to compounds of formula I and pharmaceutically acceptable salts and in vivo hydrolysable esters and amides thereof and processes for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

Aromatic amino ethers as pain relieving agents

The present invention relates to compounds of formula (I), STR1 wherein A is an optionally substituted phenyl naphthyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidyl, thienyl, thiazolyl, oxazolyl, thiadiazolyl having at least two adjacent ring carbon atoms or a bicyclic ring system, provided that the --CH(R3)N(R2)B--R1 and --OCH(R4 --)--D linking groups arm positioned in a 1,2 relationship to one another on ring carbon atoms and the ring atom positioned ortho to the --OCHR4 -- linking group (and therefore in the 3-position relative to the --CHR3 NR2 -- linking group) is not substituted; B is an optionally substituted ring system; D is an optionally substituted ring system; R1 is a variety of group as defined in the description; R2 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, phenylC1-3 alkyl or 5- or 6-membered heteroarylC1-3 alkyl; R3 is hydrogen or C1-4 alkyl; R4 is hydrogen or C1-4 alkyl; and N-oxides of NR2 where chemically possible; and S-oxides of sulphur containing rings were chemically possible; and pharmaceutically acceptable salts and in vivo hydrolysable esters and amides thereof. Process for their preparation, intermediates in theirpreparation, their use as therapeutic agents and pharmaceutical compositions containing them.

SYNTHESIS OF 6-ALKYLAMINO-3-PYRIDAZINECARBOXYLIC ACID DERIVATIVES FROM METHYL 6-CHLORO-3-PYRIDAZINECARBOXYLATE

The synthesis of methyl 6-alkylamino-3-pyridazinecarboxylates (4a-c) was accomplished by the following reaction sequence.On treatment of methyl 6-chloro-3-pyridazinecarboxylate (1) with methanolic ammonia, 6-chloro-3-pyridazinecarboxamide (5) was precipit

Fungicidal pyridazines

Plants are protected from the damaging effects of Phycomycetous fungi by a series of pyridazines of formula STR1 wherein R3 is chloro, bromo, methyl, cyano or iodo; R is chloro, bromo, iodo, methyl, cyano or furan-2-ylmethoxy; R1 is