66347-68-0

Basic information

• Product Name: cyclohexane-1,2-diyldimethanediyl dimethanesulfonate
• Synonyms: Cis-1,2-Bis(methanesulfonyloxymethyl)cyclohexane
• CAS NO: 66347-68-0
• Molecular Formula: C₁₀H₂₀O₆S₂
• Molecular Weight: 300.3922
• Mol File: 66347-68-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 495.3°C at 760 mmHg
• Flash Point: 253.3°C
• Density: 1.27g/cm³
• Vapor Pressure: 1.83E-09mmHg at 25°C
• Refractive Index: 1.481
• CAS DataBase Reference: cyclohexane-1,2-diyldimethanediyl dimethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: cyclohexane-1,2-diyldimethanediyl dimethanesulfonate(66347-68-0)
• EPA Substance Registry System: cyclohexane-1,2-diyldimethanediyl dimethanesulfonate(66347-68-0)

Safety Data

• Hazardous Substances Data: 66347-68-0(Hazardous Substances Data)

Usage

General Description

Cyclohexane-1,2-diyldimethanediyl dimethanesulfonate, also known as Methylenebis(cyclohexylamine) dimethanesulfonate, is a chemical compound frequently used as an intermediate in the synthesis of pharmaceuticals and organic compounds. It is a bifunctional crosslinking agent that is commonly employed in the production of polyurethane foams and elastomers. The compound is known for its ability to enhance the mechanical properties and stability of polyurethane materials. Additionally, it is utilized as a reagent in organic synthesis reactions, particularly in the formation of amine derivatives. Due to its versatile applications, cyclohexane-1,2-diyldimethanediyl dimethanesulfonate is widely utilized in the chemical and pharmaceutical industries.

Upstream product

• 3205-35-4 trans dimethyl cyclohexane-1,2-dicarboxylate 
• 76155-27-6 (+/-)-trans-2-(hydroxymethyl)cyclohexylmethanol 
• 124-63-0 methanesulfonyl chloride 
• 13149-00-3 1,2-cis-cyclohexanedicarboxylic anhydride 
• 17351-07-4 diethyl cyclohexane-cis-1,2-dicarboxylate 

Downstream Products

• 97920-04-2 (±)-2,2'-((1S,2R)-cyclohexan-1,2-diyl)diacetonitrile 
• 3205-37-6 (±)-2,2'-((1S,2S)-cyclohexan-1,2-diyl)diacetonitrile 
• 194861-74-0 lurasidone 
• 88-99-3 benzene-1,2-dicarboxylic acid 

Relevant articles and documents

Discovery of octahydroindenes as PAR1 antagonists

Octahydroindene was identified as a novel scaffold for protease activated receptor 1 (PAR1) antagonists. Herein, the 2-position (C2) was explored for structure-activity relationship (SAR) studies. Compounds 14, 19, and 23b showed IC50 values of 1.3, 8.6, and 2.7 nM in a PAR1 radioligand binding assay, respectively, and their inhibitory activities on platelet activation were comparable to that of vorapaxar in a platelet rich plasma (PRP) aggregation assay. This series of compounds showed high potency and no significant cytotoxicity; however, the compounds were metabolically unstable in both human and rat liver microsomes. Current research efforts are focused on optimizing the compounds to improve metabolic stability and physicochemical properties as well as potency.