6635-73-0

Usage

Structure

Carbamothioyl group attached to a phenyl ring The compound consists of a urea-like structure with a sulfur atom replacing one of the oxygen atoms, and a phenyl ring attached to this core structure.

Classification

Thiourea derivative 1-carbamothioyl-3-phenyl-thiourea belongs to the class of compounds known as thioureas, which are characterized by the presence of a硫 (sulfur) atom in their structure.

Applications

Reagent in organic synthesis The compound is used as a reagent in various organic synthesis processes, aiding in the formation of new chemical bonds and creation of new compounds.

Applications

Inhibitor in biochemical research 1-carbamothioyl-3-phenyl-thiourea is utilized as an inhibitor in biochemical research, helping to regulate or slow down specific biological processes to study their functions and mechanisms.

Enzymatic process studies

The compound has been employed in the investigation of enzymatic processes, providing insights into how enzymes function and interact with other molecules.

Therapeutic potential

Potential therapeutic agent for various diseases Researchers have explored the use of 1-carbamothioyl-3-phenyl-thiourea as a potential treatment for a range of diseases, highlighting its versatility in the field of medicine.

Antimicrobial properties

The compound has been investigated for its potential antimicrobial properties, which could make it useful in combating bacteria and other microorganisms.

Antifungal properties

1-carbamothioyl-3-phenyl-thiourea has also been studied for its potential antifungal properties, further expanding its range of applications in the field of science and industry.

InChI:InChI=1/C8H9N3S2/c9-7(12)11-8(13)10-6-4-2-1-3-5-6/h1-5H,(H4,9,10,11,12,13)

Upstream product

• 16691-28-4 S-methyl-N-phenylthiocarbamoyl-isothiourea 
• 41835-08-9 N-cyano-N'-phenylthiourea 
• 53243-23-5 2-tert-butyl-1-(phenyl-thiocarbamoyl)-isothiourea 
• 40229-47-8 (5-amino-[1,2,4]dithiazol-3-ylidene)-phenyl-amine 
• 6846-35-1 5-amino-3H-1,2,4-dithiazole-3-thione 
• 62-53-3 aniline 
• 1147550-11-5 ammonium thiocyanate 
• 103-85-5 monophenylthiourea 
• 103-72-0 phenyl isothiocyanate 
• 17356-08-0 thiourea 

Downstream Products

• 859309-86-7 6-phenylimino-6H-[1,3,5]dithiazin-4-ylamine 
• 3310-68-7 N³-phenyl-1H-1,2,4-triazole-3,5-diamine 
• 16739-02-9 5-anilino-1,2-dihydro-[1,2,4]triazole-3-thione 
• 40229-47-8 (5-amino-[1,2,4]dithiazol-3-ylidene)-phenyl-amine 
• 41834-91-7 3-phenyl-1-ureidonitrile 
• 334541-73-0 2-ethyl-1-phenyl-2-isodithiobiuret 
• 103-85-5 monophenylthiourea 
• 603-54-3 N,N-diphenylurea 
• 334541-73-0 2-ethyl-1-phenyl-2-isodithiobiuret 

Relevant academic research and scientific papers

Microwave induced improved synthesis of monoaryl thiocarbamides, 1,3-diarylthiocarbamides, 1,3-diarylcarbamides and monoaryl-2,4-dithiobiurets

The 1-arylthiocarbamides (3), 1, 3-diarylthiocarbamides (6), 1,3-diarylcarbamides (7) and 1-aryl-2,4-dithiobiurets (11) have been synthesized by the microwave induced heating of respective reactants for about 30-60 s in solvent free condition. Reaction yields are higher with reduced time, period and without the use of any solvent.

Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore

High-throughput screening for inhibitors of the human metalloprotease, methionine aminopeptidase-2 (MetAP2), identified a potent class of 3-anilino-5-benzylthio-1,2,4-triazole compounds. Efficient array and interative synthesis of triazoles led to rapid SAR development around the aniline, benzylthio, and triazole moeities. Evaluation of these analogs in a human MetAP2 enzyme assay led to the identification of several inhibitors with potencies in the 50-100 picomolar range. The deleterious effects on inhibitor potency by methylation of the anilino-triazole nitrogens, as well as the X-ray crystal structure of triazole 102 bound in the active site of MetAP2, confirm the key interactions between the triazole nitrogens, the active site cobalt atoms, and the His-231 side-chain. The structure has also provided a rationale for interpreting SAR within the triazole series. Key aniline (2-isopropylphenyl) and sulfur substituents (furanylmethyl) identified in the SAR studies led to the identification of potent inhibitors (103 and 104) of endothelial cell proliferation. Triazoles 103 and 104 also exhibited dose-dependent activity in an aortic ring tissue model of angiogenesis highlighting the potential utility of MetAP2 inhibitors as anticancer agents.

Compounds and methods

Compounds of this invention are non-peptide, reversible inhibitors of bacterial methionine aminopeptidases, useful in treating bacterial infections.

1,2,4-triazole derivatives, compositions, process of making and methods of use

Compounds of this invention are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinopathy, rheumatoid arthritis, atherosclerotic n

Synthesis of Novel 1,3,5-Dithiazine Derivatives

The reactions of benzoylacetylene, propiolic acid, and methyl propiolate with 2,4-dithiobiuret and 1-substituted and 1,5-disubstituted 2,4-dithiobiurets in glacial AcOH in the presence of HC1O4 or BF3· Et2O were used to ob