2209-23-6Relevant academic research and scientific papers
Synthesis of isomelamines and isocyanurates and their biological evaluation
Niwa, Ryuji,Kamada, Hitoshi,Shitara, Eiki,Horiuchi, Jiro,Kibushi, Nobuyuki,Kato, Tetsuzo
, p. 2314 - 2317 (2007/10/03)
The reaction of cyanogen bromide (1) with primary amines (2a-p), including arylmethylamines (21-p), gave the corresponding cyanamides (3a- p). Trimerization of 3a-p gave 1,3,5-trisubstituted 2,4,6-triiminohexahydro- 1,3,5-triazines (isomelamines) (4a-p), which were treated with hydrochloric acid to give the corresponding 1,3,5-trisubstituted 2,4,6-trioxohexahydro- 1,3,5-triazines (isocyanurates) (5a-c, f) and 1,3,5-trisubstituted 2-imino- 4,6-dioxohexahydro-1,3,5- triazines (5b'-e'). Biological evaluation of 4a- p, 5a-c, f, and 5b'-e' was carried out, and some of these compounds showed bronchodilator and positive inotropic activities.
Polymer-Supported Diaryl Selenoxide and Telluroxide as Mild and Selective Oxidizing Agents
Hu, Nan Xing,Aso, Yoshio,Otsubo, Tetsuo,Ogura, Fumio
, p. 879 - 884 (2007/10/02)
Polystyrene-bound diaryl selenoxide and telluroxide have been prepared, which behaved as mild oxidizing agents for thiols to disulfide, phosphines to phosphine oxides, hydroquinone and catechol to p- and o-benzoquinones, and thioketones to oxo compounds.The telluroxide completed these reactions in shorter periods or under milder conditions than the selenoxide.In addition, they effected novel solvent-dependent reactions of thioamides involving thioureas to 1,2,4-thiadiazoles or to nitriles.In nonacidic solvents, the dehydrosulfurization to nitriles occured in preference to the oxidative dimerization to 1,2,4-thiadiazoles, but an acidic solvent such as acetic acid promoted the latter reaction.
