6636-06-2

Usage

Uses

Used in Pharmaceutical Industry:
5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID is used as a pharmaceutical intermediate for its potential role in the development of new drugs. Its unique structure allows it to be a key component in the synthesis of various organic compounds with therapeutic properties.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID is utilized as a research compound to explore its biological activities and understand its interactions with biological targets, which may lead to the discovery of novel therapeutic agents.
Used in Organic Synthesis:
5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID serves as a building block in organic synthesis, enabling the creation of a wide range of chemical entities with diverse applications, including those in material science, agrochemicals, and specialty chemicals.

InChI:InChI=1/C11H9NO2/c13-11(14)10-7-6-9(12-10)8-4-2-1-3-5-8/h1-7,12H,(H,13,14)

Upstream product

• 70958-09-7 2,2,2-trifluoro-1-(5-phenyl-1H-pyrrol-2-yl)ethanone 
• 153783-23-4 (S)-5-Ethoxycarbonyl-2-phenyl-Δ¹-pyrroline 
• 541-41-3 chloroformic acid ethyl ester 
• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 153783-18-7 Ethyl (S)-2-(tert-butoxycarbonylamino)-5-phenyl-5-oxopentanoate 
• 952-27-2 5-Ethoxycarbonyl-2-phenyl-Δ¹-pyrroline 
• 13355-43-6 5-phenyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 3042-22-6 2-phenyl-1H-pyrrole 
• 108-86-1 bromobenzene 

Downstream Products

• 3042-22-6 2-phenyl-1H-pyrrole 
• 368210-50-8 5-phenylpyrrolo-2-carboxylic acid chloride 
• 1057214-93-3 5-phenyl-1H-pyrrole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide 
• 52179-72-3 5-phenyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 1261298-37-6 5-phenyl-N-[2-(1-piperidinylcarbonyl)phenyl]-1H-pyrrole-2-carboxamide 
• 1261298-40-1 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-one 
• 934353-30-7 3-[(5-phenyl-1H-pyrrole-2-carbonyl)-amino]-propionic acid 
• 934353-34-1 2-phenyl-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione 
• 934353-25-0 3-[(5-phenyl-1H-pyrrole-2-carbonyl)-amino]-propionic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of 5-Arylpyrrole-2-carboxylic Acids as Key Intermediates for NBD Series HIV-1 Entry Inhibitors

5-Arylpyrrole-2-carboxylic acids are important key intermediates in the synthesis of HIV-1 entry inhibitors (such as NBD-11021 and NBD-14010). Here we present a general method for the synthesis of some 5-arylpyrrole-2-carboxylic acids in three steps starting from pyrrole. By this method, the compounds could be prepared on gram scale and without chromatographic purification.

Boric acid compounds, and preparation method and use thereof

The invention relates to the fields of pharmaceutical chemistry and medicine therapeutics, concretely relates to a new boric acid compounds, and a preparation method and a use thereof, and especially relates to new substituted five-membered heterocyclic boric acid and substituted benzo five-membered boric acid compounds, and a preparation method thereof. A result of bioactive screening test of the substituted five-membered heterocyclic boric acid and substituted benzo five-membered boric acid compounds having a structure represented by a formula shown in the description shows that the compounds have a proteasome inhibition effect, and can be further used for preparing medicines for treating proteasome correlated diseases.

NMR and conformational studies of new 5-phenylpyrrole-carboxamide derivatives

The 1H and 13C NMR resonances of 22 5-(5-substituted-2-nitrophenyl)-1H-pyrrole-2-carboxamides, 22 5-(5-substituted-2-aminophenyl)-1H-pyrrole-2-carboxamides, and 9 5-phenyl-1H-pyrrole-2-carboxamides we

HIV integrase inhibitors

Nitrogen-containing heteroaryl dioxo-butyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

General method for the synthesis of 5-arylpyrrole-2-carboxylic acids

5-Arylpyrrole-2-carboxylic acids are prepared by DDQ oxidative aromatization of the corresponding ethyl 2-aryl-Δ1-pyrroline-5-carboxylate followed by basic hydrolysis.

SYNTHESIS OF PYRROLE-2-CARBOXYLIC ACIDS AND THEIR N-VINYL DERIVATIVES

Haloform cleavage of 2-trifluoroacetyl- and N-vinyl-2-trifluoroacetylpyrroles gives pyrrole-2-carboxylic acids and their N-vinyl derivatives in good yields; most of these compounds do not melt between 120-190 deg C, but rather decompose with CO2 evolution.