70958-09-7Relevant academic research and scientific papers
Synthesis of 5-Arylpyrrole-2-carboxylic Acids as Key Intermediates for NBD Series HIV-1 Entry Inhibitors
Belov, Dmitry S.,Ivanov, Vladimir N.,Curreli, Francesca,Kurkin, Alexander V.,Altieri, Andrea,Debnath, Asim K.
, p. 3692 - 3699 (2017/08/15)
5-Arylpyrrole-2-carboxylic acids are important key intermediates in the synthesis of HIV-1 entry inhibitors (such as NBD-11021 and NBD-14010). Here we present a general method for the synthesis of some 5-arylpyrrole-2-carboxylic acids in three steps starting from pyrrole. By this method, the compounds could be prepared on gram scale and without chromatographic purification.
General route to symmetric and asymmetric meso -CF3-3(5)- aryl(hetaryl)- and 3,5-diaryl(dihetaryl)-BODIPY dyes
Sobenina, Lubov N.,Vasiltsov, Alexander M.,Petrova, Olga V.,Petrushenko, Konstantin B.,Ushakov, Igor A.,Clavier, Gilles,Meallet-Renault, Rachel,Mikhaleva, Albina I.,Trofimov, Boris A.
supporting information; experimental part, p. 2524 - 2527 (2011/06/25)
A general efficient route to hitherto inaccessible symmetric and asymmetric meso-CF3-BODIPY dyes has been developed. The key stages include the reduction of available 2-trifluoroacetylpyrroles to the corresponding alcohols which are further condensed with pyrroles. The method allows the BODIPY with 3(5)aryl(hetaryl) and 3,5-diaryl(hetaryl) substituents to be readily assembled. The BODIPY dyes synthesized fluoresce (?f = 0.56-1.00) in the 560-680 nm region.
PYRROLES FROM KETOXIMES AND ACETYLENE. 38. NEW REPRESENTATIVES OF TRIFLUOROACETYLPYRROLES. SYNTHESIS AND TRANSFORMATIONS
Korostova, S. E.,Mikhaleva, A. I.,Sobenina, L. N.,Shevchenko, S. G.,Sigalov, M. V.,et al.
, p. 39 - 43 (2007/10/02)
A series of previously unknown trifluoroacetyl derivatives of pyrroles were obtained with high yields by the reaction of pyrroles, including N-vinyl-substituted pyrroles, with trifluoroacetic anhydride in the presence of pyridine at room temperature.The s
