6636-88-0

Usage

Family

Cyclopentanecarbonitrile

Structure

Contains a cyclopentane ring with a carbonitrile group attached

Additional group

Methylphenylamino group (benzene ring with a methyl group and an amino group attached)

Physical state

White solid

Solubility

Sparingly soluble in water, more soluble in organic solvents

Applications

Used in pharmaceutical and agricultural industries as a building block for the synthesis of various compounds

Potential

Under investigation for possible medicinal applications due to potential biological activity

Upstream product

• 106-49-0 p-toluidine 
• 120-92-3 cyclopentanone 
• 7677-24-9 trimethylsilyl cyanide 
• 151-50-8 potassium cyanide 

Downstream Products

• 6636-89-1 1-p-toluidino-cyclopentanecarboxylic acid amide 
• 175884-59-0 4-Imino-3-phenyl-1-p-tolyl-1,3-diaza-spiro[4.4]nonan-2-one 

Relevant academic research and scientific papers

Magnetic Fe3O4-BF3: Highly efficient Lewis acid catalyst for the synthesis of α-aminonitriles

Fe3O4 magnetic nanoparticle-supported BF3 was prepared as a new magnetically separable Lewis acid catalyst and successfully used for the one-pot synthesis of α-aminonitriles. A broad range of substrates including the aromatic and heteroaromatic aldehydes, cyclic ketones (cyclopentanone, cyclohexanone and cycloheptanone), aryl-alkyl ketones, diaryl ketones and tetralones, isatin derivatives and acenaphthenequinone were condensed with amines (aliphatic and aromatic) and trimethylsilyl cyanide. All reactions were completed in short times and products were obtained in good to excellent yields. The catalyst could be recycled and reused several times without any loss of efficiency. Finally, α-aminonitrile containing adenine was successfully synthesized.

Eco-friendly synthesis of α-aminonitriles from ketones in PEG-400 medium using potassium Hexacyanoferrate(II) as cyanide source

An efficient method for the synthesis of α-aminonitriles via one-pot three-component condensation of ketones, amines and potassium hexacyanoferrate(II) using benzoyl chloride as a promoter and PEG-400 as a reaction medium was described. This protocol has

Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC)

A structure-activity relationship study was carried out on a series of thiohydantoins and their analogues 14 which led to the discovery of 92 (MDV3100) as the clinical candidate for the treatment of hormone refractory prostate cancer.

DIARYLHYDANTOIN COMPOUNDS

The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for syntheszing them and using them in the treatment of hormone refractory prostate cancer.

Synthesis of new imidazolidinones, spiro-imidazolidinones and spiro-hydantoins

α-Alkyl/aryl-α-arylaminopropionitriles (1) and 1-arylamino-1-cyano-cyclohexanes/cyclopentanes (5) react with alkyl/arylisocyanates to afford new imidazolidinones (2, 3) and spiro-imidazolidinones (6, 7) respectively. Compounds 2 and 6 on hydrolysis give hydantoins (4) and spiro-hydantoins (8), respectively.