663603-70-1

Usage

Uses

Used in Pharmaceutical Industry:
(2Z)-3-(METHYLAMINO)-1-(2-THIENYL)PROP-2-EN-1-ONE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs.
Used in Pesticide Industry:
(2Z)-3-(METHYLAMINO)-1-(2-THIENYL)PROP-2-EN-1-ONE is used as a component in the production of pesticides, leveraging its chemical properties to enhance the effectiveness of these agricultural chemicals.
Used in Organic Synthesis:
(2Z)-3-(METHYLAMINO)-1-(2-THIENYL)PROP-2-EN-1-ONE is used as a reagent in organic synthesis processes, facilitating the creation of a variety of organic compounds for different applications.
Used in Organic Photovoltaics:
(2Z)-3-(METHYLAMINO)-1-(2-THIENYL)PROP-2-EN-1-ONE is used as a semiconducting material in the field of organic photovoltaics, where its properties contribute to the efficiency and performance of solar cells.
It is crucial to handle (2Z)-3-(METHYLAMINO)-1-(2-THIENYL)PROP-2-EN-1-ONE with care due to its potential hazards if not properly managed or utilized.

Upstream product

• 593-51-1 methylamine hydrochloride 
• 34772-98-0 3-dimethylamino-1-thiophen-2-ylpropenone 
• 88-15-3 2-Acetylthiophene 
• 109-94-4 formic acid ethyl ester 
• 130371-57-2 βeta;-oxo-βeta;-(2-thienyl)propanal sodium salt 

Downstream Products

• 116539-57-2 (R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol 
• 116539-56-1 3-(methylamino)-1-(thiophen-2-yl)propan-1-ol 

Relevant academic research and scientific papers

An efficient method for the synthesis of 2-pyridones: Via C-H bond functionalization

A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.

Ruthenium-catalyzed asymmetric hydrogenation of β-keto- enamines: An efficient approach to chiral γ-amino alcohols

A highly efficient and enantioselective hydrogenation of unprotected β-ketoenamines catalyzed with ruthenium(II) dichloro{(S)-(-)-2,2′- bis[di(3,5-xylyl)phosphino]-1,1′-binaphthyl}[(2S)-(+)-1, 1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine] {Ru[(S)-xylbinap][(S)-daipen] Cl2} has been successfully developed. This methodology provides a straightforward access to free γ-secondary amino alcohols, which are key building blocks for a variety of pharmaceuticals and natural products, with high yields (>99%) and excellent enantioselectivities (up to 99% ee) in all cases. Copyright

(E)-N-MONOALKYL-3-OXO-3-(2-THIENYL)PROPENAMINE AND PROCESS FOR PRODUCING THE SAME AND (E,Z)-N-MONOALKYL-3-OXO-3-(2-THIENYL)PROPENAMINE AND PROCESS FOR PRODUCING THE SAME

It is intended to provide a process for producing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by the general formula (I): (wherein R represents an alkyl group having 1 to 4 carbon atoms), characterized by maintaining a solution in which (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is dissolved in a solvent at 25°C or lower thereby to deposit crystals and fractionating a crystal with a particle size of 100 μm or less from the deposited crystals; and a process for producing (E,Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine, characterized by adding a water-insoluble organic solvent to a reaction solution obtained by reacting an alkali metal salt of β-oxo-β-(2-thienyl) propanal with a monoalkylamine compound, adding a seed crystal containing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine to an organic layer obtained by separation and maintaining the temperature at 25°C or lower.

PROCESS FOR PRODUCING N-MONOALKYL-3-HYDROXY-3-(2-THIENYL)PROPANAMINE AND INTERMEDIATE

The present invention provides a process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine represented by General Formula (2): wherein R is C1-4 alkyl, comprising the step of reducing (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1): wherein R is as defined above. According to the present invention, an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine which is for use as an intermediate for various pharmaceuticals can be produced in an industrially inexpensive and easy manner.