66390-00-9Relevant academic research and scientific papers
7-(2-AMINOETHYL) BENZOTHIAZOLONES
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, (2008/06/13)
There are disclosed compounds of formula I, Ar--CH. sub.2 CH 2--NH--CR 1 R 2--X--Y I in whichAr represents a group, STR1 X represents a C. sub.1-12 alkylene chain optionally interrupted or terminated by one or more groups selected from--S(O) n--,--O--,--C(Z)--, CR 6 R. sup.7, phenylmethyne,--NR 8--,--CONH--,--NHCO--and--NHCONH--, Y represents an optionally substituted aryl or cycloalkyl group,Z represents O or S, R 1, R 2, R 5 and R 9 each independently represent hydrogen or alkyl C 1-6,R 3 and R 4 represent hydrogen, or R. sup.3 and R 4 together form a group--S--,--NR 9--or--CH 2--,R 6 and R 7 independently represent hydrogen, alkyl C 1-6, fluoro, cyano, or CF. sub.3, provided that at least one of R 6 and R 7 is other than hydrogen,R 8 represents hydrogen or alkyl C 1-6, or when X is interrupted or terminated by more than one--NR 8--group may together with another R 8 group form the chain--CH 2--CH 2--, andn represents 0, 1 or 2,and pharmaceutically acceptable derivatives thereof.Processes for their production and pharmaceutical compositions and methods of treatment involving their use are also described.
Chemistry of 1,3-Oxathianes. Synthesis and Conformation of 2-Substituted 1,3-Oxathianes
Fuji, Kaoru,Ueda, Masaru,Sumi, Kenzo,Kajiwara, Kanji,Fujita, Eiichi,et al.
, p. 657 - 661 (2007/10/02)
The reaction of 2-lithio-1,3-oxathiane with a variety of electrophiles including alkyl halides and carbonyl compounds affords substitution and addition products, respectively.Alkyl metal halides such as (CH3)3SiCl, (CH3)3GeCl, and (CH3)3SnCl, or alkyl metal acetate, (CH3)3PbOAc, reacted with 1,3-oxathianyl anion to give rise to the corresponding 2-(group 14)-substituted 1,3-oxathianes (4). 2-(Methylthio)- and 2-(methylseleno)-1,3-oxathianes (6b and 6c) were prepared by a similar reaction of the anion with dimethyl disulfide and dimethyl diselenide, respectively.Other1,3-oxathianes substituted with a 2-methoxy or 2-dimethylamino group at C-2 have been synthesized to investigate the orientation of heteroatoms.Examination of their 1H and 13C NMR spectra leads to the conclusion that group 14 metals and a dimethylamino group occupy the equatorial position, while methoxy and methylthio groups favor the axial disposition due to the anomeric effect.Conclusive evidence was not obtained from the available data to decide whether 2-(methylseleno)-1,3-oxathiane (6c) exhibits the anomeric effect or not.
