663948-85-4

Basic information

• Product Name: Carbamic acid, [(3S,5S)-5-(hydroxymethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl
• Synonyms: Carbamic acid, [(3S,5S)-5-(hydroxymethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl;[(3S,5S)-5-(Hydroxymethyl)-3-pyrrolidinyl]carbamic acid tert-butyl ester;tert-butyl (3S,5S)-5-(hydroxymethyl)pyrrolidin-3-ylcarbamate;[(3S,5S)-5-(Hydroxymethyl)-3-pyrrolidinyl]-Carbamic acid 1,1-dimethylethyl ester;tert-butyl N-[(3S,5S)-5-(hydroxyMethyl)pyrrolidin-3-yl]carbaMate;tert-butyl ((3S,5S)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamate hydrochloride;Carbamic acid, [(3S,5S)-5-(hydroxymethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl [(3S,5S)-5-(Hydroxymethyl)-3-pyrrolidinyl]carbamic acid tert-butyl ester;Carbamic acid, N-[(3S,5S)-5-(hydroxymethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester
• CAS NO: 663948-85-4
• Molecular Formula: C₁₀H₂₀N₂O₃
• Molecular Weight: 216.2774
• EINECS: 604-604-1
• Product Categories: N-BOC
• Mol File: 663948-85-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 351.4 °C at 760 mmHg
• Flash Point: 166.3 °C
• Appearance: /
• Density: 1.11 g/cm³
• Refractive Index: 1.5
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.21±0.40(Predicted)
• CAS DataBase Reference: Carbamic acid, [(3S,5S)-5-(hydroxymethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(3S,5S)-5-(hydroxymethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl(663948-85-4)
• EPA Substance Registry System: Carbamic acid, [(3S,5S)-5-(hydroxymethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl(663948-85-4)

Safety Data

• Hazardous Substances Data: 663948-85-4(Hazardous Substances Data)

Usage

Uses

tert-Butyl ((3S,5S)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamate, can be used in the synthesis of various pharmaceutical and biologically active compounds. It can be used in the preparation of new chiral building blocks for novel peptide nucleic acids.

InChI:InChI=1/C10H20N2O3/c1-10(2,3)15-9(14)12-7-4-8(6-13)11-5-7/h7-8,11,13H,4-6H2,1-3H3,(H,12,14)/t7-,8-/m0/s1

Upstream product

• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 51-35-4 4R-4-hydroxyproline 
• 168263-80-7 methyl (2S,4S)-1-benzyloxycarbonyl-4-tert-butoxycarbonylaminopyrrolidine-2-carboxylate 
• 207304-86-7 (2S,4S)-1-benzyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate 
• 117811-78-6 methyl (2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxypyrrolidine-2-carboxylate 
• 113490-74-7 4(S)-azido-N-<(phenylmethoxy)carbonyl>-(S)-proline methyl ester 
• 64187-48-0 methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate 
• 380648-94-2 benzyl (2S,4S)-4-((tert-butoxycarbonyl)amino)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 

Downstream Products

• 380648-97-5 {(2S,4S)-4-t-butoxycarbonylamino-1-[(thymin-1-yl)methylcarbonyl]-pyrrolidin-2-yl}methyl 4-nitrophenyl carbonate 
• 380648-98-6 carbonic acid 1-[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-4-tert-butoxycarbonylamino-pyrrolidin-2-ylmethyl ester 4-nitro-phenyl ester 
• 1264242-42-3 C₃₉H₅₁N₅O₁₁ 

Relevant articles and documents

Pyrrolidine carbamate nucleic acids: Synthesis and DNA binding studies

An efficient solid phase synthesis of pyrrolidine carbamate nucleic acids is reported. The protected (2S, 4S)-4-aminopyrrolidine-2-methanol with nucleobases thymine and cytosine attached to the ring nitrogen through an acetyl linker can be activated as ni