6640-03-5

Basic information

• Product Name: DIMYRISTYL PHOSPHATE
• Synonyms: DIMYRISTYL PHOSPHATE;ditetradecyl phosphate;1-TETRADECANOL HYDROGEN PHOSPHATE (dimyristyl phosphate);Phosphoric acid bistetradecyl ester;Phosphoric acid hydrogen ditetradecyl ester
• CAS NO: 6640-03-5
• Molecular Formula: C₂₈H₅₉O₄P
• Molecular Weight: 490.739421
• EINECS: 229-651-0
• Mol File: 6640-03-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 555.5°C at 760 mmHg
• Flash Point: 289.8°C
• Appearance: /
• Density: 0.934g/cm³
• Vapor Pressure: 8.43E-14mmHg at 25°C
• Refractive Index: 1.459
• CAS DataBase Reference: DIMYRISTYL PHOSPHATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIMYRISTYL PHOSPHATE(6640-03-5)
• EPA Substance Registry System: DIMYRISTYL PHOSPHATE(6640-03-5)

Safety Data

• Hazardous Substances Data: 6640-03-5(Hazardous Substances Data)

Usage

General Description

DIMYRISTYL PHOSPHATE is a chemical compound that consists of a phosphate group that is esterified with myristyl alcohol. It is commonly used as an emulsifier and stabilizer in various cosmetic and personal care products, such as creams, lotions, and sunscreens. It helps to maintain the consistency of these products and improve their spreadability and texture. In addition, DIMYRISTYL PHOSPHATE also has moisturizing properties, making it beneficial for skin and hair care formulations. It is considered to be safe for use in cosmetics, as it has low toxicity and is not known to cause irritation or sensitization when used at appropriate concentrations.

InChI:InChI=1/C28H59O4P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-31-33(29,30)32-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h3-28H2,1-2H3,(H,29,30)

Upstream product

• 112-72-1 1-Tetradecanol 
• 770-12-7 O-phenyl phosphorodichloridate 

Relevant articles and documents

POLYCATIONIZED PHOSPHOLIPID DERIVATIVES

The present invention provides novel phospholipid derivatives. Furthermore, the present invention provides lipid membrane structures excellent in gene/nucleic acid introduction efficiency into a cell.

Alkyl chain length dependency in hydrolysis of liposomal phosphatidylcholine by dialkylphosphate

Because an amphiphile with a positive or negative charge, such as dialkylphosphate or stearylamine, is often added to liposomal phosphatidylcholine (PC) dispersions to prevent aggregation of the liposomes, we investigated the long-term stability of liposomes prepared from saturated PC in the presence of various amphiphiles. On storage of these liposomes at 40°C, PC was gradually hydrolyzed by dialkylphosphate, a negatively charged lipid, while neither stearylamine, a positively charged lipid, nor a non- charged lipid hydrolyzed PC at all. This hydrolysis of PC was examined using dialkylphosphates of various alkyl chain lengths (C10, C12, C14, C16, C18 and C20) and PC with different fatty acyl chain lengths (C14, C16 and C18). The rate of hydrolysis was maximum when the alkyl chain length of dialkylphosphate was almost equal to the fatty acyl chain length of PC. That is, the hydrolysis of dimyristoyl (C14) and dipalmitoyl (C16) acyl chains of PC was accelerated most by the incorporation of dimyristylphosphate (C14) and dipalmitylphosphate (C16), respectively. Distearoyl (C18) acyl chains of PC were hydrolyzed effectively by the incorporation of distearylphosphate (C18) as well as dipalmitylphosphate (C16). The hydrolysis did not occur when methyl dipalmitylphosphate was added instead of dipalmitylphosphate, or when the liposomal structure was decomposed by adding ethanol. These results suggest that dialkylphosphate and PC are aligned head to tail in liposomes and that the phosphate functional group causes the hydrolysis of the esters of PC. The incorporation of cholesterol into PC bilayers suppressed the hydrolysis of PC above the phase transition temperature (T(c)) of PC, but increased it below the T(c). The hydrolysis of PC by dialkylphosphate appears to depend on membrane fluidity and to be accelerated with increased membrane fluidity, because cholesterol reduces the fluidity of the liposomal membrane above the T(c) and enhances it below the T(c).