664342-18-1Relevant academic research and scientific papers
Synthesis of Cyclic N-Hydroxylated Ureas and Oxazolidinone Oximes Enabled by Chemoselective Iodine(III)-Mediated Radical or Cationic Cyclizations of Unsaturated N-Alkoxyureas
Peilleron, Laure,Retailleau, Pascal,Cariou, Kevin
supporting information, p. 5160 - 5169 (2019/11/11)
In this study we describe the reactivity of unsaturated N-alkoxyureas in the presence of different combinations of a hypervalent iodine(III) reagent and a bromide source or TEMPO. Three complementary cyclizations can be achieved depending on the reaction conditions. On the one hand, PIFA with pyridinium bromide leads to an oxybromination reaction. On the other hand, bis(tert-butylcarbonyloxy)iodobenzene with tetrabutylammonium bromide or TEMPO triggers aminobromination or aminooxyamination reactions, respectively. Control experiments showed that the three reactions proceed through distinct mechanisms: the first process is ionic while the other two follow a radical manifold. (Figure presented.).
PIPERLONGUMINE ANALOGUES AND USES THEREOF
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Paragraph 0169, (2019/12/04)
The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises piperlongumine derivative thereof. The selective killing of senescent cells may delay aging and/or treat age-related disorders.
Reduction of selenoamides to amines using SmI2-H2O
Thurow, Samuel,Lenardo, Eder J.,Just-Baringo, Xavier,Procter, David J.
, p. 50 - 53 (2017/11/28)
Selenoamides are selectively reduced to amines by SmI2 with H2O. The process is general for primary, secondary, and tertiary aryl and alkyl selenoamide substrates and selectively delivers amine products. The reduction proceeds under mild conditions using SmI2 activated by straightforward addition of H2O, and does not require an additional Lewis base additive.
Ring-closing metathesis and ring-closing metathesis-isomerisation approach to 1-phosphonylated 2-benzazocines
Dieltiens, Nicolai,Stevens, Christian V.,Masschelein, Kurt,Hennebel, Geert,Van der Jeught, Sarah
, p. 4295 - 4303 (2008/09/19)
An RCM strategy has been developed for the synthesis of phosphonylated benzazocines and their corresponding isomerised analogues. The aminophosphonate precursors were obtained by a one-pot three-component condensation in moderate yield.
