66464-22-0

Upstream product

• 66464-20-8 2-(2-fluorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole 
• 2386-64-3 ethylmagnesium chloride 
• 74-96-4 ethyl bromide 
• 19312-06-2 4,5-dihydro-4,4-dimethyl-2-phenoxazole 
• 597-64-8 tetraethyltin 
• 74-88-4 methyl iodide 
• 71885-44-4 4,5-dihydro-4,4-dimethyl-2-(2-methylphenyl)-2-oxazoline 
• 445-29-4 o-fluoro-benzoic acid 
• 57598-33-1 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 612-19-1 2-ethylbenzoic acid 
• 112562-01-3 2-(2-Ethyl-phenyl)-thiazolidine-3-carbothioic acid methylamide 
• 22927-13-5 2-ethylbenzaldehyde 

Relevant academic research and scientific papers

Lateral lithiation in deep eutectic solvents: regioselective functionalization of substituted toluene derivatives

The heteroatom-directed lateral lithiation of functionalized toluenes in a choline chloride-based eutectic mixture is reported. The metalations proceed within ultrafast reaction times, with a broad substrate and electrophile scope. The directing groups pr

Palladium-catalyzed alkylation of aryl C-H bonds with sp3 organotin reagents using benzoquinone as a crucial promoter

The combination of directed C-H activation, batch-wise addition of tetraalkyltin reagents, and rate enhancement by benzoquinone and microwave irradiation provides a promising strategy for the direct coupling of C-H bonds with organometallic reagents. A variety of tetraalkyltins were coupled to C-H bonds to give the alkylated products in good yields by using 5 mol % Pd(OAc)2 as the catalyst. Benzoquinone was shown to be essential for the C-H activation when substrates containing non-π-conjugated chelating groups are used. Monitoring the formation and reductive elimination of the Pd(Ar)(Me)L2 complex also revealed that benzoquinone promotes the reductive elimination step. Microwave irradiation enhances the reaction rate drastically. The versatility of this protocol was demonstrated by using substrates containing either oxazoline or pyridine as directing groups. Copyright

Optional ortho and lateral lithiations of 4,4-dimethyl-2-(o-tolyl)oxazolines

4,4-Dimethyl-2-(o-tolyl)oxazolines 1 undergo normal lateral lithiation at the benzylic position by treatment with sec-BuLi in diethyl ether at -78°C. In contrast, metalation of 1 with sec-BuLi/TMEDA in diethyl ether at the same temperature leads to ortho-

The Reactions of Carbene Intermediates from the Reaction of Trialkyl Phosphites with Dialkyl Benzoylphosphonates: Intramolecular Cyclisations of 2-Substituted Dialkyl Benzoylphosphonates

The reaction of dialkyl aroylphosphonates 1 with trialkyl phosphites leads to the formation of carbene intermediates 3 via the anionic intermediates 2.The carbene intermediates 3 (R = 2-Me, 2-Prn, 2-Bun, 2-MeS, 2-EtO and 2-EtS) have