66464-20-8

Basic information

• Product Name: 2-(2-FLUOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE
• Synonyms: 2-(2-FLUOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE;AKOS AKM01083;2-(2-fluorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole
• CAS NO: 66464-20-8
• Molecular Formula: C₁₁H₁₂FNO
• Molecular Weight: 193.22
• Mol File: 66464-20-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-FLUOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-FLUOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE(66464-20-8)
• EPA Substance Registry System: 2-(2-FLUOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE(66464-20-8)

Safety Data

• Hazardous Substances Data: 66464-20-8(Hazardous Substances Data)

Usage

Heterocyclic Compound

The compound contains a five-membered oxazole ring, which is a heterocyclic structure consisting of a ring of atoms with at least one non-carbon atom (in this case, nitrogen).

Fluorophenyl Substituent

A fluorine atom is attached to a phenyl group (a six-membered aromatic ring), which is then attached to the oxazole ring. This substituent contributes to the compound's biological activity and pharmacological properties.

Potential Applications in Pharmaceutical Industry

FDPO has shown promising pharmacological properties, particularly in the field of central nervous system disorders. This suggests that it may be useful in the development of new drugs to treat conditions such as anxiety, depression, and neurological disorders.

Pesticide and Insecticide Potential

FDPO has also been studied for its potential use as a pesticide and insecticide due to its biological activity against certain pests. This indicates that it may have applications in agriculture and pest control.

Further Research Required

While FDPO has shown promise in both pharmaceutical and pesticidal applications, more research is needed to fully understand its therapeutic and toxicological effects. This will help determine the safety and efficacy of the compound for various uses.

Upstream product

• 124-68-5 2-Amino-2-methyl-1-propanol 
• 445-29-4 o-fluoro-benzoic acid 
• 65-85-0 benzoic acid 
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• 19312-05-1 N-(2-hydroxyl-1,1-dimethylethyl) benzamide 
• 19312-06-2 4,5-dihydro-4,4-dimethyl-2-phenoxazole 
• 32664-13-4 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 446-52-6 2-Fluorobenzaldehyde 
• 128764-53-4 2-fluoro-N-(2-hydroxy-1,1-dimethylethyl)benzamide 
• 393-52-2 2-Fluorobenzoyl chloride 
• 66464-26-4 2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl-1,3-oxazole 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 
• 179116-95-1 N-(2-chloro-1,1-dimethyl-ethyl)-2-fluoro-benzamide 

Downstream Products

• 156641-63-3 4,4-dimethyl-2-<2-(2-methylphenyl)phenyl>-1,3-oxazoline 
• 1116154-15-4 (2-(2-(diphenylphosphino)phenyl)-4,4-dimethyl-4,5-dihydrooxazole)-(η4-1,5-cyclooctadiene)iridium(I) tetrakis(3,5-bis(trifluoromethyl)phenyl)borate 
• 66464-26-4 2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl-1,3-oxazole 
• 445-29-4 o-fluoro-benzoic acid 
• 111771-16-5 2-(-2-fluoro-6-iodophenyl)-4,4-dimethyl-2-oxazoline 
• 64691-33-4 2-[2-(diphenylphosphino)phenyl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole 
• 153915-36-7 cis-2,6-Dimethyl-4-[2'-(4,4-dimethyl-2-oxazolinyl)-phenyl]phenyl-methylmorpholine 
• 139287-38-0 2-tert-Butyl-benzoic acid 2-methyl-2-(methyl-trifluoromethanesulfonyl-amino)-propyl ester 
• 139287-30-2 2-tert-Butyl-benzoic acid 2-methyl-2-trifluoromethanesulfonylamino-propyl ester 
• 1077-58-3 2-tert-butylbenzoic acid 
• 84392-32-5 4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole 
• 460990-87-8 (S)-2-[2-(3,4-dimethyl-1H-phosphol-1-yl)phenyl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole 
• 87306-63-6 2-<2-(1,1-dimethylethyl)phenyl>-4,4-dimethyl-2-oxazoline 
• 66464-23-1 2,2'-bis(4,4-dimethyl-4,5-dihydrooxazol-2-yl)biphenyl 

Relevant articles and documents

Rhodium-catalyzed Si-F exchange reaction between fluorobenzenes and a disilane. Catalytic reaction involving cleavage of C-F bonds

The reaction of functionalized fluorobenzenes, such as fluoroacetophenones and (fluorophenyl)oxazolines, with Me3SiSiMe3 in the presence of a catalytic amount of a rhodium complex results in a site-selective Si-F exchange to give ort

Aerobic C(sp2)-H Hydroxylations of 2-Aryloxazolines: Fast Access to Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores

The direct hydroxylation of 2-aryloxazolines via a deprotonative magnesiation using TMPMgCl·LiCl and subsequent oxidation with molecular oxygen or air as a green oxidant is reported. This method proceeds under mild conditions at room temperature with high regioselectivity and chemoselectivity. The obtained phenols exhibit tunable luminescence properties, induced by excited-state intramolecular proton transfer. This method opens a new opportunity for the sustainable synthesis of luminescent organic molecules.

Palladium-catalyzed electrophilic C–H fluorination of arenes using oxazoline as a removable directing group

Dimethyloxazoline was rationally designed to act as a removable ortho-directing group (DG) for the palladium-catalyzed C–H electrophilic fluorination of arenes. Using NFSI as the fluorinating agent, and Pd(II), Ag(I) catalytic system, electrophilic C(sp2–H) ortho-fluorination took place on a variety of aryl substrates to afford the corresponding mono- and di-fluorinated products.