66476-02-6

Upstream product

• 121-33-5 vanillin 
• 100-44-7 benzyl chloride 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 103-80-0 phenylacetyl chloride 
• 90-05-1 2-methoxy-phenol 
• 4112-89-4 2-methoxyphenyl 2-phenylacetate 
• 274925-96-1 1-(4-benzyloxy-3-methoxyphenyl)-2-phenyl-ethanone 
• 103-82-2 phenylacetic acid 
• 73049-08-8 4-(1-Hydroxy-2-phenyl-ethyl)-2-methoxy-phenol 
• 274925-95-0 1-(4-benzyloxy-3-methoxyphenyl)-2-phenyl-ethanol 

Downstream Products

• 73049-08-8 4-(1-Hydroxy-2-phenyl-ethyl)-2-methoxy-phenol 
• 274925-88-1 1-(3,4-diacetoxy-5-nitrophenyl)-2-phenyl-ethanone 
• 274925-86-9 Nebicapone 
• 383382-82-9 1-(3,4-dihydroxy-2-nitro-phenyl)-2-phenyl-ethanone 
• 383383-05-9 1-(4-hydroxy-3-methoxy-2-nitro-phenyl)-2-phenyl-ethanone 
• 873296-37-8 acetic acid 2-methoxy-4-phenylacetyl-phenyl ester 
• 3391-75-1 2-methoxy-4-((E)-phenylethenyl)phenol 
• 274925-97-2 BIA 3-270 

Relevant academic research and scientific papers

A convenient one-pot completely stereoselective synthesis of trans-4-Hydroxystilbenes and its derivatives and X-ray structure of its precursor

The synthesis of E-isomer of 4-Hydroxystilbene and its derivatives 3 by reductive elimination of the carbonyl function in 2-phenyl-1-(4-hydroxyphenyl)ethan-1-one and its derivatives 2 and the X-ray structure of 2a are described.

Substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them

New compounds of formula I are described The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders, where a reduction in the O-methylation of catecholamines may be of therape

Synthesis of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase

A homologous series of novel nitro-catechol structures (7a-7e) were synthesized and tested as inhibitors of the enzyme catechol-O-methyltransferase (COMT). Increasing chain length was found to have significant impact on both brain penetration and duration

Improved method for demethylation of nitro-catechol methyl ethers

Several nitro-catechol compounds, useful as inhibitors of COMT were obtained in excellent yield and purity via an improved procedure for demethylation of the corresponding methyl ethers using aluminium chloride and pyridine in ethyl acetate.

Synthesis of deoxybenzoins

Zinc chloride-phosphoryl chloride is an efficient condensing agent for the preparation of hydroxy(methoxy)deoxybenzoins at room temperature directly from phenols and arylacetic acids.

Quinone Dehydrogenation. Oxidation of Benzylic Alcohols with 2,3-Dichloro-5,6-dicyanobenzoquinone

2,3-Dichloro-5,6-dicyanobenzoquinone (DDQ) reacts with primary and secondary aryl-substituted alcohols under mild conditions in dioxane solution to give the corresponding carbonyl compounds in high yields.In contrast to other oxidants, DDQ can be applied advantageously for the oxidation of hydroxyaryl-substituted alcohols.A mechanism involving participation of the phenolic hydroxyl group in the dehydrogenation reaction is discussed.Oxidations of hydroxyaryl-substituted alcohols by DDQ in methanolsolution resulting in the formation of benzoquinones by loss of the hydroxyaryl side chain are interpreted in terms of phenol oxidation.An example of a pyridine-catalyzed Smiles rearrangement of an o-hydroxy-substituted diphenyl ether is reported.