66483-40-7

Basic information

• Product Name: Butanedioic acid, (4-methylphenyl)-
• CAS NO: 66483-40-7
• Molecular Formula: C11H12O4
• Molecular Weight: 208.214
• Mol File: 66483-40-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Butanedioic acid, (4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanedioic acid, (4-methylphenyl)-(66483-40-7)
• EPA Substance Registry System: Butanedioic acid, (4-methylphenyl)-(66483-40-7)

Safety Data

• Hazardous Substances Data: 66483-40-7(Hazardous Substances Data)

Upstream product

• 622-97-9 1-ethenyl-4-methylbenzene 
• 124-38-9 carbon dioxide 
• 109971-38-2 C₁₉H₂₇N₃O₄ 
• 14111-33-2 diethyl 2-(4-methylbenzylidene)malonate 
• 151-50-8 potassium cyanide 
• 18300-87-3 ethyl 2-cyano-3-p-tolylacrylate 
• 104-87-0 4-methyl-benzaldehyde 
• 766-97-2 4-n-methylphenylacetylene 

Downstream Products

• 34319-19-2 N-methyl-2-p-tolylsuccinimide 

Relevant articles and documents

Method for synthesizing succinic acid compounds

The invention provides a method for synthesizing succinic acid compounds. The method specifically comprises the following steps: adding a substrate, a photocatalyst and an alkali into a reaction tube,adding a reducing agent and a solvent under the atmosphere of CO2, conducting reacting under the irradiation of visible light, carrying out quenching treatment after the raw materials react completely, and then conducting separating and purifying to obtain a dicarboxylated product of olefin, namely a succinic acid compound. The photocatalyst is 4CzIPN or Ir[(ppy)2(dtbppy)]PF6 and the like, and the reaction substrate comprises 1,1-diaryl ethylene, a monoaryl substituted olefin compound, an acrylate compound and allene. According to the scheme provided by the invention, the reaction conditionsare mild, the applicability of the reaction substrate is wide, and the yield is basically not influenced under the condition that the reaction substrate is amplified to the gram scale; and meanwhile,the invention overcomes the defects of high toxicity of reagents and harsh reaction conditions in the prior art, and has a good industrial application prospect.

Discovery, stereospecific characterization and peripheral modification of 1-(pyrrolidin-1-ylmethyl)-2-[(6-chloro-3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinolines as novel selective κ opioid receptor agonists

A novel series of 1-(pyrrolidin-1-ylmethyl)-2-[(3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinoline derivatives maj-3a-maj-3u were synthesized and evaluated in vitro for their binding affinity at κ-opioid receptors. Maj-3c displayed the highest affinity for κ-opioid receptors (Ki = 0.033 nM) among all the compounds evaluated. Furthermore, all four stereoisomers of compound 3c were prepared, and (1S,18S)-3c was identified as the most potent (Ki = 0.0059 nM) κ-opioid receptor agonist among the four stereoisomers. Maj-3c produced significant antinociception (ED50 = 0.000406 mg kg-1) compared to U-50,488H and original BRL 52580 in the acetic acid writhing assay, but its strong sedative effect (ED50 = 0.000568 mg kg-1) observed in the mouse rotation test reduced its druggability. To minimize the central nervous system side effects, a series of hydroxyl-containing analogs of maj-3c were synthesized, and maj-11a was found to be a potent κ-opioid receptor agonist (Ki = 35.13 nM). More importantly, the dose for the sedative effect (ED50 = 9.29 mg kg-1) of maj-11a was significantly higher than its analgesic dose (ED50 = 0.392 mg kg-1), which made it a promising peripheral analgesic candidate compound with weak sedative side effects.

Synthesis of 3-aryl thiophenes from disodium 2-aryl succinates: Role of red phosphorus

Role played by red phosphorus in the synthesis of 3-aryl thiophenes from disodium 2-aryl succinates using P4S10 discussed. A new simple method for the synthesis of 2-(4-methylphenyl)succinic acid is also described.