18300-87-3Relevant articles and documents
Synthesis of KOH/SnO2 solid superbases for catalytic Knoevenagel condensation
Xie, Jun,Chen, Lang,Au, Chak-Tong,Yin, Shuang-Feng
, p. 30 - 33 (2015)
KOH/SnO2 solid superbases of specific morphology and uniform pore structure were synthesized. The SnO2 support was prepared by reflux digestion using graphene oxide as template and employed for the loading of KOH by means of grinding
Mesoporous carbon nitride as a metal-free base catalyst in the microwave assisted Knoevenagel condensation of ethylcyanoacetate with aromatic aldehydes
Ansari, Mohd Bismillah,Jin, Hailian,Parvin, Mst. Nargis,Park, Sang-Eon
, p. 211 - 216 (2012)
High nitrogen containing mesoporous carbon nitride (MCN) was synthesized and investigated as a metal-free base catalyst for the Knoevenagel condensation of ethylcyanoacetate with aromatic aldehydes. The catalyst was found to be efficient for the Knoevenag
Polystyrene-supported chloroaluminate ionic liquid as a new heterogeneous Lewis acid catalyst for Knoevenagel condensation
Parvanak Boroujeni, Kaveh,Jafarinasab, Mina
, p. 1067 - 1070 (2012)
Non-hygroscopic polystyrene-supported chloroaluminate ionic liquid was prepared from the reaction of Merrifield resin with 1-methylimidazole followed by reaction with aluminum chloride. This Lewis acidic ionic liquid is environmentally friendly heterogene
Amino-functionalized mesostructured cellular foam silica: A highly efficient and recyclable catalyst in the Knoevenagel condensation reaction
Dong, Hao,Yang, Hongyuan,Zhang, Tengfei,Liu, Qing
, p. 1204 - 1215 (2019)
Mesostructured cellular foam silica was functionalized by an amino group (MCF-NH2) using the postsynthesis grafting method and utilized as a recyclable catalyst for the Knoevenagel reaction to afford α, β-unsaturated compounds. The catalyst was systematic
MOFs assembled from C 3symmetric ligands: Structure, iodine capture and role as bifunctional catalysts towards the oxidation-Knoevenagel cascade reaction
Zhang, Ying-Ying,Liu, Qing,Zhang, Lin-Yan,Bao, Yu-Mei,Tan, Jing-Yi,Zhang, Na,Zhang, Jian-Yong,Liu, Zhen-Jiang
, p. 647 - 659 (2021)
Three new NiII/CoII-metal organic frameworks were self-assembled by the reaction of C3 symmetric 1,3,5-tribenzoic acid (H3BTC) and 2,4,6-tris(4-pyridyl)-1,3,5-triazine (4-TPT) ligands and NiII/CoII salts under solvothermal conditions. Isomorphous MOF1 and MOF2 exhibit a 3D pillar-layer framework based on binuclear M2(OH)(COO)2 units connected by tritopic BTC3- and 4-TPT ligands with a novel (3,5)-connected topology net. MOF3 displays a 3-fold interpenetrated 3D network exhibiting a (3,4)-connected topology net. The porous MOF3 can reversibly take up I2. The activated MOFs contain both Lewis acid (NiII center) and basic (uncoordinated pyridyl or carboxylic groups) sites, and act as bifunctional acid-base catalysts. The catalytic measurements demonstrate that the activated MOF3 exhibits good activities for benzyl alcohol oxidation and the Knoevenagel reaction and can be recycled and reused for at least four cycles without losing its structural integrity and high catalytic activity. Thus, the catalytic properties for the oxidation-Knoevenagel cascade reaction have also been studied.
Calcined Dolomite: An Efficient and Recyclable Catalyst for Synthesis of Α, Β-Unsaturated Carbonyl Compounds
Yang, Hongyuan,Dong, Hao,Zhang, Tengfei,Zhang, Qi,Zhang, Guangwei,Wang, Peng,Liu, Qing
, p. 778 - 787 (2019)
Abstract: Calcined dolomite was utilized as a low-cost and efficient catalyst for the Knoevenagel condensation of aldehydes with active methylene compounds such as malononitrile and ethyl cyanoacetate to afford substituted α, β-unsaturated carbonyl compou
Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular modeling study
Elhagali, Gameel A. M.,Mahmoud, N. A.,Ragab, Ahmed,Saadon, Khadija E.,Taha, Nadia M. H.
, (2022/05/17)
A new series of pyridine-2-one and pyrazole derivatives were designed and synthesized based on cyanoacrylamide derivatives containing 2,4-dichlro aniline and 6-methyl 2-amino pyridine as an aryl group. Condensation of cyanoacrylamide derivatives 3a–d with different active methylene (malononitrile, ethyl cyanoacetate cyanoacetamide, and ethyl acetoacetate) in the presence of piperidine as basic catalyst afforded the corresponding pyridinone derivatives 4a–c, 5, 9, and 13. Furthermore, the reaction of cyanoacrylamide derivatives 3a–d with bi-nucleophile as hydrazine hydrate and thiosemicarbazide afforded the corresponding pyrazole derivatives 14a,b and 16. The newly designed derivatives were confirmed and established based on the elemental analysis and spectra data (IR, 1H NMR, 13C NMR, and mass). The in vitro antibacterial activity was evaluated against four bacterial strains with weak to good antibacterial activity. Moreover, the results indicated that the most active derivatives 3a, 4a, 4b, 9, and 16 might lead to antibacterial agents, especially against B. subtilis and P. vulgaris. The DFT calculations were performed to estimate its geometric structure and electronic properties. In addition, the most active pyridinone and pyrazole derivatives were further evaluated for in silico physicochemical, drug-likeness, and toxicity prediction. These derivatives obeyed all Lipinski’s and Veber’s rules without any violation and displayed non-immunotoxin, non-mutagenic, and non-cytotoxic. Molecular docking simulation was performed inside the active site of Topoisomerase IV (PDB:3FV5). It displayed binding energy ranging from -14.97?kcal/mol to -18.86?kcal/mol with hydrogen bonding and arene–cation interaction. Therefore, these derivatives were suggested to be good antibacterial agents via topoisomerase IV inhibitor. Graphical abstract: [Figure not available: see fulltext.]
Highly Active Copper(I)-Chalcogenone Catalyzed Knoevenagel Condensation Reaction Using Various Aldehydes and Active Methylene Compounds
Mannarsamy, Maruthupandi,Prabusankar, Ganesan
, (2021/10/05)
First copper(I) chalcogenones catalysed Knoevenagel Condensation reactions have been reported. No illustration of the utilization of this copper-chalcogenone complex class in Knoevenagel Condensation catalysis can be found. Thus, copper(I) bis(benzimidazole-2-chalcogenone) catalysts [Cu(L1)4]+BF4? (1) and [Cu(L2)4]+BF4? (2) (L1 = bis(1-isopropyl-benzimidazole-2-selone)-3-ethyl; L2 = bis(1-isopropyl-benzimidazole-2-thione)-3-ethyl) have been utilized as catalysts in the Knoevenagel Condensation reactions. These copper(I) chalcogenone catalysts have shown high efficiency for the catalytic Knoevenagel Condensation of aryl aldehydes and active methylene compounds. In particular, complex 2, exhibit the best catalytic activities. The scope of the catalytic reactions has been investigated with 22 different molecules. The excellent catalytic activity has been depicted for various types of substrates with either electron-rich or deficient aryl aldehydes. The present investigation features relatively mild reaction conditions with good functional group tolerance and excellent yields. Graphic Abstract: The first copper(I)-chalcogenone complexes catalysed Knoevenagel Condensation reactions?have also been investigated, and revealed the best catalytic activities. [Figure not available: see fulltext.]
