66490-32-2

Basic information

• Product Name: 6-chloro-3-methylbenzo[b]thiophene-2-carboxylic acid
• Synonyms: 6-chloro-3-methylbenzo[b]thiophene-2-carboxylic acid;6-chloro-3-methylbenzothiophene-2-carboxylic acid
• CAS NO: 66490-32-2
• Molecular Formula: C₁₀H₇ClO₂S
• Molecular Weight: 226.67938
• Mol File: 66490-32-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-chloro-3-methylbenzo[b]thiophene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-3-methylbenzo[b]thiophene-2-carboxylic acid(66490-32-2)
• EPA Substance Registry System: 6-chloro-3-methylbenzo[b]thiophene-2-carboxylic acid(66490-32-2)

Safety Data

• Hazardous Substances Data: 66490-32-2(Hazardous Substances Data)

Usage

Chemical class

Benzo[b]thiophene

Properties

Carboxylic acid derivative, chlorine atom at the 6th position, methyl group at the 3rd position of the benzo[b]thiophene ring

Applications

Potential applications in pharmaceutical and agrochemical industries

Potential uses

Biological activities, starting material for synthesis of various organic compounds

Handling

Caution required due to potential hazards

Upstream product

• 175711-83-8 4’-chloro-2’-fluoroacetophenone 
• 1415968-74-9 methyl 6-chloro-3-methylbenzo[b]thiophene-2-carboxylate 

Downstream Products

• 1415968-56-7 6-chloro-3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)benzo[b]thiophene-2-carboxylic acid 

Relevant articles and documents

AMINOISOXAZOLINE COMPOUNDS AS AGONISTS OF ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel aminoisoxazoline compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS

The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.