66496-58-0

Upstream product

• 13505-06-1 4-nitro-pyridin-3-ol 
• 20443-98-5 2,6-Dichlorobenzyl bromide 
• 15128-82-2 3-hydroxy-2-nitropyridine 
• 15258-73-8 2,6-dichlorobenzyl alcohol 
• 83-38-5 2,6-dichlorobenzaldehyde 

Downstream Products

• 107229-64-1 2-Amino-3-(2,6-dichlorobenzyloxy)pyridine 
• 756503-57-8 3-(2,6-dichlorobenzyloxy)-5-bromopyridin-2-amine 

Relevant academic research and scientific papers

Spiro compounds, preparation method thereof, intermediate, pharmaceutical composition and application

The invention discloses a spiro compound as shown in a formula I, a pharmaceutically acceptable salt, a hydrate, a solvate, an optical isomer or a prodrug of the spiro compound, as well as a preparation method, an intermediate, a pharmaceutical composition and an application of the spiro compound. The spiro compound disclosed by the invention has the activity of serving as protein kinase inhibitors and tyrosine kinase inhibitors such as c-Met, and the spiro compound can be used for treating diseases caused by the abnormal activity of kinases, such as cancer, or used for preparing medicaments for treating the diseases.

AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.