107229-64-1

Basic information

• Product Name: 2-Amino-3-(2,6-dichlorobenzyloxy)pyridine
• Synonyms: 2-Amino-3-(2,6-dichlorobenzyloxy)pyridine
• CAS NO: 107229-64-1
• Molecular Formula: C₁₂H₁₀Cl₂N₂O
• Molecular Weight: 269
• Mol File: 107229-64-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Amino-3-(2,6-dichlorobenzyloxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-(2,6-dichlorobenzyloxy)pyridine(107229-64-1)
• EPA Substance Registry System: 2-Amino-3-(2,6-dichlorobenzyloxy)pyridine(107229-64-1)

Safety Data

• Hazardous Substances Data: 107229-64-1(Hazardous Substances Data)

Usage

Appearance

white solid

Contains

amino group, pyridine ring, dichlorobenzyloxy group

Uses

building block in synthesis of pharmaceuticals and organic compounds, development of drugs targeting specific receptors or enzymes

Importance

valuable tool in medicinal chemistry and pharmaceutical research

Safety

handle with proper precautions due to potential hazards

Upstream product

• 15258-73-8 2,6-dichlorobenzyl alcohol 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 16867-03-1 2-amino-3-hydroxypyridine 
• 20443-98-5 2,6-Dichlorobenzyl bromide 
• 66496-58-0 3-(2,6-dichloro-benzyloxy)-2-nitro-pyridine 
• 2014-83-7 1,3-Dichloro-2-chloromethyl-benzene 

Downstream Products

• 151411-88-0 N-(3-(2,6-Dichlorobenzyloxy)-pyrid-2-yl)-N'-(4-chlorophenyl)thiourea 
• 107229-78-7 8-(2,6-Dichlorobenzyloxy)-2-methylimidazo[1,2-a]pyridine 
• 173158-99-1 8-(2,6-Dichloro-benzyloxy)-2-methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester 

Relevant articles and documents

Spiro compounds, preparation method thereof, intermediate, pharmaceutical composition and application

The invention discloses a spiro compound as shown in a formula I, a pharmaceutically acceptable salt, a hydrate, a solvate, an optical isomer or a prodrug of the spiro compound, as well as a preparation method, an intermediate, a pharmaceutical composition and an application of the spiro compound. The spiro compound disclosed by the invention has the activity of serving as protein kinase inhibitors and tyrosine kinase inhibitors such as c-Met, and the spiro compound can be used for treating diseases caused by the abnormal activity of kinases, such as cancer, or used for preparing medicaments for treating the diseases.

AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 1. Construction of the basic framework

A novel class of potent, selective, and orally active non-peptide bradykinin (BK) B2 receptor antagonists were designed and synthesized starting from 8-benzyloxyimidazo[1,2-α]pyridine derivative 2. The unique screening lead (2) was discovered b