664972-58-1

Basic information

• Product Name: 2,7-bis(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-6-yl phenyl sulfone
• Synonyms: 2,7-bis(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-6-yl phenyl sulfone
• CAS NO: 664972-58-1
• Molecular Formula: C₂₆H₂₁N₃O₂S
• Molecular Weight: 439.52884
• Mol File: 664972-58-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,7-bis(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-6-yl phenyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,7-bis(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-6-yl phenyl sulfone(664972-58-1)
• EPA Substance Registry System: 2,7-bis(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-6-yl phenyl sulfone(664972-58-1)

Safety Data

• Hazardous Substances Data: 664972-58-1(Hazardous Substances Data)

Upstream product

• 151293-15-1 5-amino-3-(4-methylphenyl)-1H-pyrazole 
• 38488-14-1 2-(phenylsulfonyl)-1-(p-tolyl)ethanone 
• 122-51-0 orthoformic acid triethyl ester 
• 1334688-02-6 C₁₈H₁₈O₄S 

Relevant articles and documents

Single step synthesis of new fused pyrimidine derivatives and their evaluation as potent Aurora-A kinase inhibitors

A simple, facile, efficient and one pot three-component procedure for the synthesis of pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines and pyrimido[1,2-a]benzimidazoles ring systems incorporating phenylsulfonyl moiety was developed via the reaction

Synthesis and analgesic/anti-inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety

A series of pyrazolo[1,5-a]pyrimidine, triazolo[1,5-a]pyrimidine, and pyrimido[1,2-a]benzimidazole ring systems incorporating phenylsulfonyl moiety were synthesized via the reaction of 3-(N,N-dimethylamino)-1-aryl-2-(phenylsulfonyl)prop-2-en-1-one derivatives 2a,b with appropriate nitrogen nucleophiles. The analgesic and anti-inflammatory activities of the newly synthesized compound were investigated in vivo. 3-Bromo-2-phenyl-6-(phenylsulfonyl)-7-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine (5e) was found to have an excellent analgesic activity in comparison with indomethacin as a reference drug, while the highest anti-inflammatory effect was observed in the case of 2-(4-bromophenyl)-6-(phenylsulfonyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine (5d). From the structure-activity relationship (SAR) point of view, the analgesic/anti-inflammatory activity of pyrazolo[1,5-a]pyrimidine derivatives was found to be much higher than triazolo[1,5-a]pyrimidine and pyrimido[1,2-a]benzimidazole derivatives.