38488-14-1

Basic information

• Product Name: Phenyl[2-oxo-2-(4-methylphenyl)ethyl] sulfone
• Synonyms: 1-(4-Methylphenyl)-2-(phenylsulfonyl)ethanone;4-Methylphenacylphenyl sulfone;4'-Methyl-α-(phenylsulfonyl)acetophenone;Phenyl[2-oxo-2-(4-methylphenyl)ethyl] sulfone;α-(Phenylsulfonyl)-4'-methylacetophenone;β-Oxo-4-methylphenethylphenyl sulfone;1-p-Tolyl-2-(phenylsulfonyl)ethanone
• CAS NO: 38488-14-1
• Molecular Formula: C₁₅H₁₄O₃S
• Molecular Weight: 274.34
• Mol File: 38488-14-1.mol
• Article Data: 50

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Phenyl[2-oxo-2-(4-methylphenyl)ethyl] sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: Phenyl[2-oxo-2-(4-methylphenyl)ethyl] sulfone(38488-14-1)
• EPA Substance Registry System: Phenyl[2-oxo-2-(4-methylphenyl)ethyl] sulfone(38488-14-1)

Safety Data

• Hazardous Substances Data: 38488-14-1(Hazardous Substances Data)

Upstream product

• 622-97-9 1-ethenyl-4-methylbenzene 
• 618-41-7 Benzenesulfinic acid 
• 108-98-5 thiophenol 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 
• 873-55-2 sodium benzenesulfonate 
• 96475-75-1 4‐methylacetophenone oxime acetate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 766-97-2 4-n-methylphenylacetylene 
• 1866-39-3 4-methylcinnamic acid 
• 89108-49-6 1-(1-azidovinyl)-4-methyl benzene 
• 80-17-1 benzenesufonyl hydrazide 
• 66616-85-1 α-(4-methylphenyl)acrylic acid 
• 106-38-7 para-bromotoluene 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 

Downstream Products

• 122772-71-8 (E)-2-Benzenesulfonyl-3-pyridin-2-yl-1-p-tolyl-propenone 
• 122772-69-4 (E)-2-Benzenesulfonyl-3-pyridin-3-yl-1-p-tolyl-propenone 
• 122772-70-7 (Z)-2-Benzenesulfonyl-3-thiophen-2-yl-1-p-tolyl-propenone 
• 122-00-9 para-methylacetophenone 
• 882-33-7 diphenyldisulfane 
• 1304145-18-3 (Z)-4-phenylsulfonyl-1,3-di(4-methylphenyl)-2-buten-1-one 
• 122772-65-0 (E)-2-Benzenesulfonyl-3-(2-hydroxy-phenyl)-1-p-tolyl-propenone 
• 122773-04-0 4-Benzenesulfonyl-5-(2-chloro-phenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole 
• 122772-64-9 1-(4'-methylphenyl)-3-phenyl-2-phenylsulphonyl-2-propen-1-one 
• 122772-68-3 (E)-2-Benzenesulfonyl-3-(2-chloro-phenyl)-1-p-tolyl-propenone 
• 122772-66-1 (E)-2-Benzenesulfonyl-3-(4-chloro-phenyl)-1-p-tolyl-propenone 
• 1610556-08-5 4-(3-acetyl-4-(phenylsulfonyl)-5-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide 
• 1610556-11-0 1-(4-methylphenyl)-2-(phenylsulfonyl)ethanone oxime 

Relevant articles and documents

Synthesis and x-ray structure of (1 Z,2 Z)-1,2-Bis(2-(phenylsulfonyl)-1-(4-tolyl)ethylidene)hydrazine

The title compound (1Z,2Z)-1,2-bis(2-(phenylsulfonyl)-1-(4-tolyl)ethylidene)hydrazine (5) was prepared, in 78% yield, by the reaction of 2-(phenylsulfonyl)-1-(4-tolyl)ethan-1-one (3) with hydrazine hydrate in acetic acid at 90°C under microwave irradiatio

Copper-catalyzed aerobic oxidative cross-coupling reactions of vinylarenes with sulfinate salts: A direct approach to β-ketosulfones

A copper-catalyzed aerobic oxidative cross-coupling reactions for the synthesis of β-ketosulfones via formation of a C[sbnd]S bond has been demonstrated. Promoted by the crucial copper catalyst, perfect selectivity and good to excellent yields could be achieved. This method, including inexpensive copper catalyst, wide functional group tolerance, and open air conditions, make it very attractive and practical. More importantly, it also provides a versatile tool for the construction of β-ketosulfones from basic starting materials under mild conditions.

Chemoenzymatic Oxosulfonylation-Bioreduction Sequence for the Stereoselective Synthesis of β-Hydroxy Sulfones

A series of optically active β-hydroxy sulfones has been obtained through an oxosulfonylation-stereoselective reduction sequence in aqueous medium. Firstly, β-keto sulfones were synthesized from arylacetylenes and sodium sulfinates to subsequently develop the carbonyl reduction in a highly selective fashion using alcohol dehydrogenases as biocatalysts. Optimization of the chemical oxosulfonylation reaction was investigated, finding inexpensive iron(III) chloride hexahydrate (FeCl3 ? 6H2O) as the catalyst of choice. The selection of isopropanol in the alcohol-water media resulted in high compatibility with the enzymatic process for enzyme cofactor recycling purposes, providing a straightforward access to both (R)- and (S)-β-hydroxy sulfones. The practical usefulness of this transformation was illustrated by describing the synthesis of a chiral intermediate of Apremilast. Interestingly, the development of a chemoenzymatic cascade approach avoided the isolation of β-keto sulfone intermediates, which allowed the preparation of chiral β-hydroxy sulfones in high conversion values (83–94 %) and excellent optical purities (94 to >99 % ee).