664994-80-3Relevant academic research and scientific papers
Total synthesis of antibacterial dibromotyrosine derived alkaloid purpuramine-K#
Reddy, S. Malla,Srinivasulu,Venkateswarlu
, p. 2757 - 2762 (2007/10/03)
The first total synthesis of a dibromotyrosine derived alkaloid purpuramine K 1 reported for possible anti-bacterial activity against gram-positive bacteria viz: Staphylococcus aureus, Bacillus subtilis, Bacillus sphaericus and gram-negative bacteria like Chromobacterium violaceum, Klebsiella aerogenes, and Pseudomonas aeruginosa has been achieved. The synthesis involves preparation of methyl-3-bromopropyl carbamate 6, and Boc protected 2-[3,5-dibromo, 4-hydroxy phenyl] ethyl amine 13 which is followed by coupling of these two structural fragments to give corresponding ether 14. After deprotection of Boc group in compound 14, it is reacted with 4-hydroxyphenyl pyruvic acid oxime derivative 17 using EDCI/HOBT to give compound 18, which is further transformed to purpuramine K.
Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge
Kotoku, Naoyuki,Tsujita, Hiroaki,Hiramatsu, Atsushi,Mori, Chinatsu,Koizumi, Noriko,Kobayashi, Motomasa
, p. 7211 - 7218 (2007/10/03)
An efficient total synthesis of bastadin 6 (1), a cyclic tetramer of brominated tyrosine derivatives from the marine sponge, Ianthella basta, with selective anti-angiogenic activity, was accomplished. We developed a novel Ce(IV)-mediated oxidative couplin
