66504-83-4 Usage
Uses
Used in Pharmaceutical Synthesis:
(1R,2S)-1-P-TOLYL-CYCLOPROPANE-1,2-DICARBOXYLIC ACID is used as a key intermediate in the synthesis of various drugs and pharmaceuticals. Its unique structure and reactivity allow for the creation of diverse chemical entities with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (1R,2S)-1-P-TOLYL-CYCLOPROPANE-1,2-DICARBOXYLIC ACID serves as a valuable building block for the development of novel therapeutic agents. Its cyclopropane ring and p-tolyl substituent can be further modified to explore new chemical space and discover compounds with improved pharmacological properties.
Used in Organic Synthesis:
(1R,2S)-1-P-TOLYL-CYCLOPROPANE-1,2-DICARBOXYLIC ACID is utilized as a versatile building block in organic synthesis, enabling the construction of complex molecular architectures. Its unique structural features and reactivity make it an attractive candidate for the synthesis of various organic compounds with potential applications in materials science, agrochemistry, and other fields.
Check Digit Verification of cas no
The CAS Registry Mumber 66504-83-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,0 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 66504-83:
(7*6)+(6*6)+(5*5)+(4*0)+(3*4)+(2*8)+(1*3)=134
134 % 10 = 4
So 66504-83-4 is a valid CAS Registry Number.
66504-83-4Relevant academic research and scientific papers
1-Aryl-3-azabicyclohexanes, a New Series of Nonnarcotic Analgesic Agents
Epstein, Joseph W.,Brabander, Herbert J.,Fanshawe, William J.,Hofmann, Corris M.,McKenzie, Thomas C.,et al.
, p. 481 - 490 (2007/10/02)
A series of 1-aryl-3-azabicyclohexanes was synthesized by hydride reduction of 1-arylcyclopropanedicarboximides.Hydroxyphenyl analogues 20, 22, and 24 were prepared by EtSNa-DMF ether cleavage of the corresponding methoxyphenyl analogues 2m, 2n, and 23, respectively, with the secondary amines 20 and 22 going through the N-formyl intermediates 19 and 21.The p-ethoxy analogue 26 was obtained by O-ethylation of 19, followed by base hydrolysis of the amide 25.The greatest analgesic potency in mouse writhing and rat paw-pain assays was observed for para-substituted compounds.Bicifadine, 1-(4-methylphenyl)-3-azabicyclohexane (2b), was the most potent member of the series and is presently undergoing clinical trials in man.Analgesic activity of 2b is limited to the (+) enantiomer 2v, which has the 1R,5S absolute configuration as determined by single-crystal X-ray analysis.The N-methyl analogue (27d) of 2b showed significant analgesic potency, whereas the N-allyl (27a), N-(cyclopropylmethyl) (27b), and N-(n-hexyl) (27c) analogues were inactive.Bicifadine (2b) showed a nonnarcotic profile different from analogous azabicycloalkane and 3-phenylpyrrolidine analgesics.
