6652-42-2

Basic information

• Product Name: 3,4,5-triphenyl-1,3-oxazol-2(3H)-one
• CAS NO: 6652-42-2
• Molecular Formula: C₂₁H₁₅NO₂
• Molecular Weight: 313.3493
• Mol File: 6652-42-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 466.5°C at 760 mmHg
• Flash Point: 235.9°C
• Density: 1.257g/cm³
• Vapor Pressure: 7.06E-09mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 3,4,5-triphenyl-1,3-oxazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-triphenyl-1,3-oxazol-2(3H)-one(6652-42-2)
• EPA Substance Registry System: 3,4,5-triphenyl-1,3-oxazol-2(3H)-one(6652-42-2)

Safety Data

• Hazardous Substances Data: 6652-42-2(Hazardous Substances Data)

Usage

General Description

3,4,5-triphenyl-1,3-oxazol-2(3H)-one is a compound with the molecular formula C22H15NO2. It is a derivative of oxazole, a five-membered aromatic heterocycle with one oxygen and one nitrogen atom in the ring. 3,4,5-triphenyl-1,3-oxazol-2(3H)-one is a white crystalline solid with a melting point of around 210-212 °C. It is used in organic synthesis and chemical research as a building block for the construction of more complex organic molecules. Its structure and properties make it a valuable reagent in the field of drug discovery and development, as well as in the production of specialty chemicals and materials. The compound may also have potential applications in the pharmaceutical industry due to its biological activity and potential therapeutic properties.

Upstream product

• 15045-02-0 (+/-)-2,3-Epoxy-1,2-diphenylpropan-1-one 
• 103-71-9 phenyl isocyanate 
• 5722-91-8 1,2-diphenyl-2-(phenylamino)ethanone 
• 591-50-4 iodobenzene 
• 1011269-13-8 N-phenyl-N-phenylethynylcarbamic acid tert-butyl ester 
• 98-80-6 phenylboronic acid 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 871897-83-5 (α'-oxo-bibenzyl-α-yl)-phenyl-carbamic acid ethyl ester 
• 112223-25-3 (+/-)-α-phenylcarbamoyloxy-deoxybenzoin; O-phenylcarbamoyl-dl-benzoin 

Downstream Products

• 60072-20-0 3-phenyl-3H-phenanthro[9,10-d]oxazol-2-one 
• 89338-13-6 11-Oxo-9a,12,12a-triphenyl-9a,11,12,12a-tetrahydrooxazo(4,5-b)phenanthro(9,10-e)-1,4-dioxine 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 13730-10-4 1,2,4,5-tetraphenyl-1H-imidazole 
• 102064-14-2 3,4,5-triphenyl-4-oxazoline-2-thione 
• 81640-85-9 N-benzoyl-N-(α-benzoylbenzyl)aniline 

Relevant articles and documents

Controlled Synthesis of 1,3,5-Oxadiazin-2-ones and Oxazolones through Regioselective Iodocyclization of Ynamides

Two efficient processes based on the iodocyclization of ynamides have been developed: (i) N-alkynyl tert-butyloxycarbamates were found to undergo a rare 6-exo-dig ring closure reaction affording 1,3,5-oxadiazin-2-ones by using acetonitrile as solvent; (ii) In the absence of acetonitrile, N-alkynyl tert-butyloxycarbamates could undergo 5-endo-dig cyclization providing oxazolones. (Chemical Equation Presented).

Preparation of 3,4,5-trisubstituted oxazolones by pd-catalyzed coupling of n -alkynyl tert -butyloxycarbamates with aryl halides and related electrophiles

A novel palladium-catalyzed approach for the assembly of 3,4,5-trisubstituted oxazolones has been achieved by the coupling of N-alkynyl tert-butyloxycarbamates with aryl halides and related electrophiles, which involves an oxidative addition followed by oxypalladation/reductive elimination. The reaction provides a convenient access to diversely substituted oxazolones in satisfactory yields and shows good functional group compatibility.

Cyclization Reaction of Bis(tributylstannylated) α-Ketols with Heterocumulenes. Preparation of O,O-Vinylene Imino- and Thiocarbonates

Aromatic α-ketols reacted with diethylaminotributylstannane at 60 deg C to afford a mixture of (Z)- and (E)-1,2-bis(tributylstannyloxy)-1,2-diarylethenes, which were allowed to react with organic isothiocyanates and carbon disulfide to give substituted O,