66521-29-7

Upstream product

• 111-26-2 hexan-1-amine 
• 14813-69-5 (phenylethynyl)mercury chloride 
• 536-74-3 phenylacetylene 
• 98-86-2 acetophenone 
• 98-85-1 1-Phenylethanol 
• 99-91-2 para-chloroacetophenone 
• 32366-25-9 1-azidoethylbenzene 

Downstream Products

• 1524-15-8 4,4,4-trifluoro-3-hydroxy-1-phenylbutan-1-one 
• 55386-59-9 N-(1-phenylethyl)hexane-1-amine 

Relevant academic research and scientific papers

Ruthenium Bisammine Complex and Its Reaction with Aryl Azides

A ruthenium bisammine complex was formed in the reaction of ruthenium 1,4-dibenzyltetraazadiene complex with primary amines at room temperature, which was a versatile precursor for the synthesis of various Ru(II) complexes through ligand exchange reactions. In the reaction with azidobenzene, ruthenium 1,4-diphenyltetraaza-1,3-diene complex was formed, while ruthenium imido complexes were given in the reaction with bulky aryl azides such as 2-azido-1,3-dimethylbenzene and 2-azido-1,3-diisopropylbenzene. The ruthenium imido complexes showed high catalytic activity in the reaction of alkyl azides with primary amines to afford N-substituted imines.

Reductive amination using a combination of CaH2 and noble metal

Amines were prepared by a reductive amination reaction in the presence of calcium hydride and Pt/C. The in situ formation of water seems to be the key to activate CaH2 to reduce the intermediate imine.

Zn-Co double metal cyanides as heterogeneous catalysts for hydroamination: A structure-activity relationship

Zn-Co double metal cyanide (DMC) materials are effective heterogeneous catalysts for intermolecular hydroaminations. Using the reaction of 4-isopropylaniline with phenylacetylene as a test, the effect of different catalyst synthesis procedures on the cata

Formation of imines by selective gold-catalysed aerobic oxidative coupling of alcohols and amines under ambient conditions

The formation of imines by aerobic oxidative coupling of mixtures of alcohols and amines was studied using gold nanoparticles supported on titanium dioxide, TiO2, as a heterogeneous catalyst. The reactions were performed at ambient conditions (room temperature and atmospheric pressure) and occurred with excellent selectivity (above 98%) at moderate conversion under optimized conditions. The effect of catalytic amounts of different bases was studied, along with reaction temperature and time. Utilisation of a selective catalyst system that uses dioxygen as an oxidant and only produces water as by-product represents a new green reaction protocol for imine formation.

Erbium(III) triflate: A valuable catalyst for the synthesis of aldimines, ketimines, and enaminones

Aldimines, ketimines, and enaminones can be obtained under erbium(III) inflate catalysis. The reaction mechanism is that typical of imine synthesis. The role of the catalyst is demonstrated for the synthesis of aromatic imines. In contrast to CeCl3/NaI addition to unsaturated aldehydes, which results in Michael addition, no Michael adduct was observed under erbium(III) triflate catalysis. Georg Thieme Verlag Stuttgart.

Alkynylmercury Chloride or Acetate as Intermediates in the Mercury(II) Salt-promoted Addition of Aliphatic and Aromatic Amines to Terminal Acetylenes

Arylaminomercuriation of terminal acetylenes has been carried out with aliphatic amines to yield amines and enamines.Phenylethynylmercury chloride is shown to be an intermediate in the mercury(II) salt-promoted addition of aliphatic and aromatic amines to terminal alkynes.