66548-54-7

Basic information

• Product Name: 3-CHLORO-6-(4-CYANOPHENYL)PYRIDAZINE
• Synonyms: 3-CHLORO-6-(4-CYANOPHENYL)PYRIDAZINE
• CAS NO: 66548-54-7
• Molecular Formula: C₁₁H₆ClN₃
• Molecular Weight: 215.64
• Product Categories: pharmacetical
• Mol File: 66548-54-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 450.7°C at 760 mmHg
• Flash Point: 226.3°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 2.59E-08mmHg at 25°C
• Refractive Index: 1.637
• PKA: -0.27±0.10(Predicted)
• CAS DataBase Reference: 3-CHLORO-6-(4-CYANOPHENYL)PYRIDAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-6-(4-CYANOPHENYL)PYRIDAZINE(66548-54-7)
• EPA Substance Registry System: 3-CHLORO-6-(4-CYANOPHENYL)PYRIDAZINE(66548-54-7)

Safety Data

• Hazardous Substances Data: 66548-54-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H6ClN3/c12-11-6-5-10(14-15-11)9-3-1-8(7-13)2-4-9/h1-6H

Upstream product

• 135034-10-5 3-chloro-6-iodopyridazine 
• 36725-37-8 6-(4-bromophenyl)-4,5-dihydropyridazin-3(2H)-one 
• 50636-57-2 6-(4-bromophenyl)-3(2H)-pyridazin-3-one 
• 52240-10-5 4-(1,6-dihydro-6-oxo-3-pyridazinyl)benzonitrile 

Downstream Products

• 67820-85-3 N'-[6-(4-cyano-phenyl)-5-methyl-pyridazin-3-yl]-hydrazinecarboxylic acid tert-butyl ester 
• 67820-75-1 N'-[6-(4-cyano-phenyl)-pyridazin-3-yl]-hydrazinecarboxylic acid ethyl ester 
• 67821-02-7 4-[4-methyl-6-(N-methyl-hydrazino)-pyridazin-3-yl]-benzonitrile 
• 149354-16-5 (3R,5S)-3-Allyl-5-[[6-(4-cyanophenyl)-3-pyridazinyl]oxymethyl]-1-(3-phenylpropyl)-2-pyrrolidinone 

Relevant articles and documents

Synthesis and Bioevaluation of 3,6-Diaryl-[1,2,4]triazolo[4,3-b] Pyridazines as Antitubulin Agents

A series of 3,6-diaryl-[1,2,4]triazolo[4,3-b]pyridazines were designed as a class of vinylogous CA-4 analogues. The easily isomerized (Z,E)-butadiene linker of vinylogous CA-4 was replaced by a rigid [1,2,4]triazolo[4,3-b]pyridazine scaffold. Twenty-one target compounds were synthesized and exhibited moderate to potent antiproliferative activity. The compound 4q with a 3-amino-4-methoxyphenyl moiety as the B-ring, comparable to CA-4 (IC50 = 0.009-0.012 μM), displayed the highly active antiproliferative activity against SGC-7901, A549, and HT-1080 cell lines with IC50 values of 0.014, 0.008, and 0.012 μM, respectively. Tubulin polymerization experiments indicated that 4q effectively inhibited tubulin polymerization, and immunostaining assay revealed that 4q significantly disrupted tubulin microtubule dynamics. Moreover, cell cycle studies revealed that compound 4q dramatically arrested cell cycle progression at G2/M phase in A549 cells. Molecular modeling studies showed that 4q could bind to the colchicine binding site on microtubules.

2-pyrrolidinones, pharmaceutical compositions containing these compounds and processes for preparing them

The invention relates to cyclic imino derivatives of general formula wherein A, B, E, X2 to X5 and Y are defined as in claim 1, the stereoisomers, tautomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions which contain these compounds and processes for preparing them.

Hypotensive alkyl-3-[6-(aryl)-3-pyridazinyl]-carbazates

This disclosure describes novel alkyl 3-[6-(aryl)-3-pyridazinyl]-carbazates useful as hypotensive agents in mammals. SP CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of our copending application Ser. No. 692,254, filed June 3, 1976 now abandoned, which in turn is a continuation-in-part of our abandoned application Ser. No. 552,024, filed Feb. 24, 1975 now abandoned.