50636-57-2

Basic information

• Product Name: 6(4-BROMOPHENYL)-3(2H)PYRIDAZINONE
• Synonyms: 6(4-BROMOPHENYL)-3(2H)PYRIDAZINONE;6-(4-bromophenyl)-3(2H)-pyridazin-3-one;6-(4-Bromophenyl)pyridazin-3-ol;3-(4-bromophenyl)-1H-pyridazin-6-one
• CAS NO: 50636-57-2
• Molecular Formula: C₁₀H₇BrN₂O
• Molecular Weight: 251.08
• Mol File: 50636-57-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 247-250°C
• Appearance: /
• Density: 1.61 g/cm³
• CAS DataBase Reference: 6(4-BROMOPHENYL)-3(2H)PYRIDAZINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6(4-BROMOPHENYL)-3(2H)PYRIDAZINONE(50636-57-2)
• EPA Substance Registry System: 6(4-BROMOPHENYL)-3(2H)PYRIDAZINONE(50636-57-2)

Safety Data

• Hazardous Substances Data: 50636-57-2(Hazardous Substances Data)

Usage

General Description

6(4-Bromophenyl)-3(2H)pyridazinone is a chemical compound with the molecular formula C10H7BrN2O. It is a heterocyclic compound with a pyridazine ring and a bromophenyl group attached to it. 6(4-BROMOPHENYL)-3(2H)PYRIDAZINONE has potential applications in pharmaceutical and agricultural industries, as it exhibits biological activities such as anti-inflammatory and antifungal properties. The presence of the bromophenyl group enhances its medicinal properties and makes it a promising candidate for the development of new drugs. Additionally, it can be used as a building block in organic synthesis to create more complex molecules with diverse applications.

Upstream product

• 36725-37-8 6-(4-bromophenyl)-4,5-dihydropyridazin-3(2H)-one 
• 1353682-60-6 ethyl 5-(4-bromophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-7-carboxylate 
• 35338-15-9 (Z)-4-(4-Bromo-phenyl)-4-oxo-but-2-enoic acid ethyl ester 
• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 108-86-1 bromobenzene 
• 99-90-1 para-bromoacetophenone 
• 298-12-4 Glyoxilic acid 
• 1031756-56-5 2-benzylamino-4-(4-bromophenyl)-4-oxobutanoic acid 
• 20972-38-7 (E)-4-(4-bromophenyl)-4-oxobut-2-enoic acid 
• 1220109-80-7 2-phenylmercapto-3-(4-bromobenzoyl)propionic acid 

Downstream Products

• 66548-50-3 3-(p-bromophenyl)-6-chloropyridazine 
• 52240-10-5 4-(1,6-dihydro-6-oxo-3-pyridazinyl)benzonitrile 
• 100716-06-1 6-(4-bromophenyl)-2-ethoxycarbonylmethyl-3(2H)-2,3-dihydropyridazin-3-one 
• 66548-54-7 3-chloro-6-(4-cyano-phenyl)-pyridazine 
• 67820-75-1 N'-[6-(4-cyano-phenyl)-pyridazin-3-yl]-hydrazinecarboxylic acid ethyl ester 
• 67821-02-7 4-[4-methyl-6-(N-methyl-hydrazino)-pyridazin-3-yl]-benzonitrile 
• 67820-95-5 N'-(6-phenyl-pyridazin-3-yl)-hydrazinecarboxylic acid ethyl ester 
• 67820-76-2 N'-[6-(4-bromo-phenyl)-pyridazin-3-yl]-hydrazinecarboxylic acid ethyl ester 
• 67820-85-3 N'-[6-(4-cyano-phenyl)-5-methyl-pyridazin-3-yl]-hydrazinecarboxylic acid tert-butyl ester 
• 923098-74-2 ethyl 2-(3-(4-bromophenyl)-6-oxopyridazin-1(6H)-yl)propanoate 
• 1177257-69-0 6-(4-bromophenyl)-2-(prop-2-ynyl)pyridazin-3(2H)-one 
• 1177257-68-9 2-allyl-6-(4-bromophenyl)pyridazin-3(2H)-one 
• 922879-75-2 methyl 2-(3-(4-bromophenyl)-6-oxopyridazin-1(6H)-yl)acetate 
• 104106-95-8 2-(3-(4-bromophenyl)-6-oxopyridazin-1(6H)-yl)acetamide 

Relevant articles and documents

Rhodium(III)-Catalyzed Alkynylation of 4-Arylphthalazin-1(2H)-one Scaffolds via C-H Bond Activation

Selective C–H bond alkynylation toward modular access to material and pharmaceutical molecules is of great desire in modern organic synthesis. Disclosed herein is rhodium(III)-catalyzed selective C–H bond mono-/bialkynylation of 4-aryl phthalazin-1(2H)-one was developed. The silver salt AgSbF6 are demonstrated to play a vital role in promoting the bialkynylation reactions. The present alkynylation strategy is simple, efficient, and features high functional group tolerance and broad substrate scope under an air atmosphere. Additionally, 6-aryl pyridazin-3(2H)-one scaffold is amenable to the selective monoalkynylation and sequential bialkynylation, respectively.

Features of reactions of (E)-[(2-aroyl)ethenyl]triphenylphosphonium bromides with binucleophiles

Reactions of (E)-[(2-aroyl)ethenyl]triphenylphosphonium bromides with hydroxylamine hydrochloride resulted in the formation of oximes undergoing α-phenyl migration when reacted with aqueous alkali. Reaction of these salts with hydrazine hydrochloride and

Copper-catalyzed aerobic dehydrogenation of C-C to C=C bonds in the synthesis of pyridazinones

A simple and efficient procedure for the synthesis of pyridazin-3(2H)-ones through copper-catalyzed dehydrogenation of a single C-C bond of 4,5-dihydropyridazin-3(2H)-ones to a C=C bond with oxygen as the terminal oxidant is described. Functional groups including hydroxy, carboxylic, bromo, chloro, cyano, nitro and alkoxy were all tolerated under the reaction conditions. Moreover, this methodology was applied to the preparation of a series of structurally similar N-substituted 6-phenylpyridazinone compounds containing fluorine. The dehydrogenation reactions exhibit good yields and selectivity. Copper-catalyzed dehydrogenation of a C-C bond of 4,5-dihydropyridazinones to a C=C bond with oxygen as the terminal oxidant is described. Various functional groups were tolerated under the reaction conditions. The method was also applied to the preparation of a series of N-substituted 6-phenylpyridazinones containing fluoride. The dehydrogenation reactions exhibit good yields and selectivity.