66548-75-2

Upstream product

• 117979-34-7 (E,E)-N-<3-(dimethylamino)-1-(3-nitrophenyl)-2-propenylidene>-4H-1,2,4-triazol-4-amine 
• 624-84-0 formic acid hydrazide 
• 58059-33-9 3-chloro-6-(3-nitrophenyl)pyridazine 
• 54558-01-9 3-(m-Nitrophenyl)-6-oxo-1,6-dihydropyridazine 
• 117979-27-8 (E)-N-<1-(3-nitrophenyl)ethylidene>-4H-1,2,4-triazol-4-amine 
• 121-89-1 3-Nitroacetophenone 

Downstream Products

• 66548-77-4 6-(3-aminophenyl)-1,2,4-triazolo<4,3-b>pyridazine 
• 66548-78-5 N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide 

Relevant academic research and scientific papers

A New and Improved Synthesis of 6-Aryl-1,2,4-triazolopyridazines

A new and improved synthesis of 6-aryl-1,2,4-triazolopyridazines is described.This methodology provides the title compounds under mild conditions and in high yields.The first step comprises the condensation of an aryl methyl ketone with a 4-amino-1

Synthesis and Anxiolytic Activity of 6-(Substituted-phenyl)-1,2,4-triazolopyridazines

The synthesis of a series of 6-(substituted-phenyl)-1,2,4-triazolopyridazines (VIII) is reported.Some of these derivatives show activity in tests predictive of anxiolytic activity (a) protection against pentylenetetrazole-induced convulsions; (b)

Method for treating anxiety in mammals

This disclosure describes compositions of matter useful as anxiolytic agents and the method of meliorating anxiety in mammals therewith; the active ingredients of said compositions of matter being certain substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines or the pharmacologically acceptable acid-addition salts thereof.

6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents

This disclosure describes novel substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines useful as hypotensive agents.