58059-33-9

Upstream product

• 54558-01-9 3-(m-Nitrophenyl)-6-oxo-1,6-dihydropyridazine 
• 141-30-0 3,6-dichlorpyridazine 
• 13331-27-6 m-nitrobenzene boronic acid 
• 20375-65-9 3-chloro-6-phenylpyradazine 
• 6328-00-3 4-(3-nitro-phenyl)-4-oxo-butyric acid 
• 52239-76-6 3-(m-Nitrophenyl)-6-oxo-1,4,5,6-tetrahydropyridazine 

Downstream Products

• 93182-09-3 3-(4-hydroxypiperidino)-6-(3-nitrophenyl)pyridazine 
• 66548-74-1 3-methyl-6-(3-nitrophenyl)-[1,2,4]triazolo[4,3-b]pyridazine 
• 66548-75-2 6-(3-nitro-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine 
• 108655-21-6 3-(m-Aminophenyl)pyridazine 
• 1010448-70-0 3-(2-furyl)-6-(3-nitrophenyl)[1,2,4]triazolo[4,3-b]pyridazine 
• 108810-90-8 3-chloro-6-(3-aminophenyl)pyridazine 
• 67820-97-7 N'-[5-methyl-6-(3-nitro-phenyl)-pyridazin-3-yl]-hydrazinecarboxylic acid methyl ester 
• 76970-07-5 3-methyl-6-(3-acetamidophenyl)-1,2,4-triazolo<4,3-b>pyridazine 
• 66548-76-3 3-methyl-6-[3-(amino)phenyl]-1,2,4-triazolo[4,3-b]pyridazine 
• 66548-77-4 6-(3-aminophenyl)-1,2,4-triazolo<4,3-b>pyridazine 

Relevant academic research and scientific papers

Synthesis and Bioevaluation of 3,6-Diaryl-[1,2,4]triazolo[4,3-b] Pyridazines as Antitubulin Agents

A series of 3,6-diaryl-[1,2,4]triazolo[4,3-b]pyridazines were designed as a class of vinylogous CA-4 analogues. The easily isomerized (Z,E)-butadiene linker of vinylogous CA-4 was replaced by a rigid [1,2,4]triazolo[4,3-b]pyridazine scaffold. Twenty-one target compounds were synthesized and exhibited moderate to potent antiproliferative activity. The compound 4q with a 3-amino-4-methoxyphenyl moiety as the B-ring, comparable to CA-4 (IC50 = 0.009-0.012 μM), displayed the highly active antiproliferative activity against SGC-7901, A549, and HT-1080 cell lines with IC50 values of 0.014, 0.008, and 0.012 μM, respectively. Tubulin polymerization experiments indicated that 4q effectively inhibited tubulin polymerization, and immunostaining assay revealed that 4q significantly disrupted tubulin microtubule dynamics. Moreover, cell cycle studies revealed that compound 4q dramatically arrested cell cycle progression at G2/M phase in A549 cells. Molecular modeling studies showed that 4q could bind to the colchicine binding site on microtubules.

INHIBITORS OF C-MET AND USES THEREOF

The present invention relates to compounds and methods use as inhibitors of c-Met. Certain compounds of the subject invention have the following structural formula (I). Other compounds of the subject invention have structural formulas as defined herein. A

Substituted diazabicycloalkane derivatives

Compounds of formula (I) [in-line-formulae]Z-Ar1—Ar2??(I) [/in-line-formulae] wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

Amide compounds

The present invention is a compound and pharmaceutical composition comprising a compound of formula (I): wherein R1is a 4-(lower) alkyl-imidazol-1-yl or a 4,5-di(lower) alkyl-imidazol-1-yl group, R2is a hydrogen atom or a lower alkyl

QUANTITATIVE DETERMINATION OF THE ELECTRONIC EFFECTS OF 3- AND 4-PYRIDAZINYL GROUPS FROM NMR SPECTRAL DATA FOR ISOMERIC AMINOPHENYL- AND PHENYLPYRIDAZINES

The previously unknown aminophenylpyridazines were synthesized.The inductive and resonance constants of 3- and 4-pyridazinyl groups were calculated on the basis of 1H and 13C NMR spectral data for isomeric aminophenyl- and phenylpyridazines in dimethyl sulfoxide (DMSO).

Synthesis and Anxiolytic Activity of 6-(Substituted-phenyl)-1,2,4-triazolopyridazines

The synthesis of a series of 6-(substituted-phenyl)-1,2,4-triazolopyridazines (VIII) is reported.Some of these derivatives show activity in tests predictive of anxiolytic activity (a) protection against pentylenetetrazole-induced convulsions; (b)

Method for treating anxiety in mammals

This disclosure describes compositions of matter useful as anxiolytic agents and the method of meliorating anxiety in mammals therewith; the active ingredients of said compositions of matter being certain substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines or the pharmacologically acceptable acid-addition salts thereof.

6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents

This disclosure describes novel substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines useful as hypotensive agents.