66552-45-2Relevant academic research and scientific papers
Site-Selective Cu-Catalyzed Alkylation of Α-Amino Acids and Peptides toward the Assembly of Quaternary Centers
San Segundo, Marcos,Correa, Arkaitz
, p. 3893 - 3898 (2018)
The CuI-catalyzed selective α-alkylation of α-amino acid and peptide derivatives with 2-alkyl-1,3-dioxolanes is reported. This oxidative coupling is distinguished by its site-specificity, high diastereoselectivity, and chirality preservation and exhibits absolute chemoselectivity for N-aryl glycine motifs over other amino acid units. Collectively, the method allows for the assembly of challenging quaternary centers, as well as compounds derived from natural products of high structural complexity, which may provide ample opportunities for late-stage functionalization of peptides.
A transformation of N-alkylated anilines to N-aryloxamates
Zhu, Xiao-He,Zhang, Xin,Xin, Hong-Xing,Yan, Hong
, p. 1542 - 1547 (2013/09/02)
Transformation of N-alkylated anilines to N-aryloxamates was studied using ethyl 2-diazoacetoacetate as an alkylating agent and dirhodium tetraacetate (Rh2(OAc)4) as the catalyst. The general applicability of the reaction as a synthetic method for N-aryloxamates was studied with a number of substituted N-alkylated anilines. The results revealed that the oxamate was formed by a radical reaction with molecular O2 and Rh 2(OAc)4 as initiator. Copyright
